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- Need help A patient with sickle cell anemia is given oxygen to decrease the sickling of the cells. What would be the reaction (if any) if the patient was given glucose instead of oxygen and why?Briefly describe the role that phosphofructokinase plays in cellular respiration. Describe the impact a lack of phosphofructokinase would have on cellular respiration and one sign and/or symptom that may be present in someone who suffers from this disorder.In angiogenic endothelial cells, pyruvate is converted to lactate (generating 2 ATP per glucose) rather than being completely oxidized (which would generate ~32 ATP by oxidative phosphorylation). Explain why angiogenic cells generate ATP anaerobically.
- Characterizing Glycolysis List the reactions of glycolysis that a. are energy consuming (under standard-stale conditions), b. are energy yielding (under standard-state conditions), c. consume ATP. d. yield ATP e. are strongly influenced by changes in concentration of substrate and product because of their molecularity. f. are at or near equilibrium in the erythrocyte (see Table 18.2).The control of which enzyme exerts the most control on glycolysis? hexokinase phosphofructokinase glucose-6-phosphatase aldolaseTrue or false 1. Cytochrome p450 is considered to be the “universal oxygenase” 2. In alzheimer’s and Parkinson’s diseases, there is hyperphosphorylation of tau that leads to the intracellular accumulation of tau in the form of neurofibrillary tangles.
- Although phosphoesters are generally not energetic enough to donate the phosphate to make a high energy bond (e.g., a phosphoanhydride), the phosphate in PEP is used to convert ADP to ATP in the pyruvate kinase reaction. Carefully explain the ‘quirk’ of this reaction that makes it energetically feasible.True statements regarding the TCA cycle EXCEPT Its metabolic product is ATP. It produces carbon dioxide and the reducing equivalents NADH and FADH2. It is a process in the mitochondrial matrix. It utilizes a 2-carbon acetyl group, condense with a 4-carbon oxaloacetate to form a tricarboxylic citrate.1. State if true or false a. Gluconeogenesis is the exact opposite of the glycolytic pathway b. The end-product of glycolysis is Acetyl CoA c. There is no enzyme being secreted in the stomach for carbohydrate digestion d.Glycerol 3-phosphate shuttle, which is active in skeletal muscles and in the brain, bypasses Complex I and II of ETC resulting to less energy produced compared to malate-aspartate shuttle. e. Insoluble NSP has high water holding capacity and will increase the intestinal transit time of digesta.
- . Carbonic anhydrase of erythrocytes (M, 30,000) has one of the highest turnover numbers known. It catalyzes the reversible hydration of CO₂. H₂O + CO₂ H₂CO3 This is an important process in the transport of CO₂ from the tissues to the lungs. If 3 µg of pure carbonic anhydrase catalyzes the hydration of 0.10 g of CO₂ in 1 min at 37 °C at Vmax, what is the turnover number (kcat) of carbonic anhydrase? Keat = 3.79 ×10-¹4 Incorrect I minWhich among the following catalyse dehydration step in the TCA cycle Isocitrate dehydrogenase Enolase Fumarase Succinyl thiokinaseWhich of the following products of the non-oxidative stage of PPP is an intermediate in the glycolysis pathway? Group of answer choices Glyceraldehyde-3-phosphate Xylulose-5-phosphate Erythrose-4-phosphate Ribose-5-phosphate
