6. The molecule below is (loosely) inspired by a recently disclosed Phase III clinical candidate drug used to treat refractory chronic cough. Propose three unique retrosynthetic disconnections on this molecule, clearly mark them, then show the intermediates and reagents (if appropriate) that would be used to synthesize the molecule in a forward direction. You can choose to disconnect the final product at three unique positions, or can further retrosynthetically disconnect intermediates from previous fragments. F

6. The molecule below is (loosely) inspired by a recently disclosed Phase III clinical candidate drug used to treat refractory chronic cough. Propose three unique retrosynthetic disconnections on this molecule, clearly mark them, then show the intermediates and reagents (if appropriate) that would be used to synthesize the molecule in a forward direction. You can choose to disconnect the final product at three unique positions, or can further retrosynthetically disconnect intermediates from previous fragments. F

Organic Chemistry: A Guided Inquiry

2nd Edition

ISBN:9780618974122

Author:Andrei Straumanis

Publisher:Andrei Straumanis

Chapter13: Substitution

Section: Chapter Questions

Problem 4E

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