33. A drug rapidly distributes in total body water and has an elimination half-life of 8 hours. In a patient who weighs 80 kg (176 lb; total body water of 50 L), an intravenousdrip is started that will maintain a drug concentration in plasma of 20 mg/L at steady state. The time it will take (in hours) from the start of the intravenous drip for plasmadrug concentration to reach 18 mg/L (90% of the steady state value) is closest to which of the following?COA) 8B) 16C) 32D) 64OE) 128

Drug: A drug is any substance, natural or synthetic, that when taken into the body, alters its…

Answered: 33. A drug rapidly distributes in total…

Curren'S Math For Meds: Dosages & Sol

11th Edition

ISBN:9781305143531

Author:CURREN

Publisher:CURREN

Chapter9: Parenteral Medication Labels And Dosage Calculation

Section: Chapter Questions

Problem 7.8P

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4) A 45-year old woman weighing 68 kg is admitted to hospital after a drug overdose. A toxic plasma concentration of 264 mg/mL is recorded on admission. After 35 hours, a plasma concentration of 8.25mg/ml is recorded. Given this information, calculate the half life for this drug.(Assume the distribution is complete and that the elimination is described by a first-order process.)unit- hours
n 10-kg infant requires a continuous infusion of a drug to run at 1 mL/hr to deliver 3 mcg of drug/kg/min. Calculate the milligrams of drug that must be added to a 100-mL IV infusion solution.
(7).At 10 p.m. , a patient must receive 1g of Cefazolin (Ancef) intravenous piggyback (1.V.P.B.) in 250ml of Dextrose 5% in water (D5W), to be infused over 45 minutes. The drop factor is 10gtt = 1ml . What is the correct flow rate of this antibiotic solution? 10 qtts/min 45 qtts/min 31. 249 qtts/min 55.55 qtts/min
200 mg of drug is given IV, plasma drug concentration is 70 mg/L. Calculate the Vd? Where most of the drug is distributed to? Note: Volume of Distribution (L) = Amount of drug in the body (mg) / Plasma concentration of drug (mg/L). O a. Vd=14000 L, drug is mostly outside of plasma, distributed to tissues O b. Vd=2.8 L, drug is mostly outside of plasma, distributed to tissues OC. Vd =0.35 L, drug is mostly in plasma Od. Vd=2.8 L, drug is mostly in plasma O e. Vd =0.35 L, drug is mostly outside of plasma, distributed to tissues
A 72-year-old adult patient who weighs 78 kg is prescribed by the doctor “Potassium Chloride 40meq in 1L to run for 8 hours” via the peripheral line for a potassium level of 3.3 mEq/L that was drawn this morning. Note: 10 mEq of potassium chloride increases serum potassium levels by approximately 0.1 mEq/.L The concentration of potassium for intravenous administration via a peripheral line should not exceed 40mmol / 500 mL 10 mEq/hr maximum infusion rate; not to exceed 200 mEq dose/24hr Administration rates above 20mmol/hour require cardiac monitoring. How much will the order medication “Potassium Chloride 40meq in 1L to run for 8 hours” raise the patient's potassium level in a day? Is it still within the normal potassium serum levels, which is 3.5–5.0 mEq/L? Does the order comply with the maximum concentration of potassium to be administered peripherally? Does the order’s infusion rate do not exceed the standard maximum infusion rate? Does the order require cardiac monitoring?
The peak plasma concentration achieved after the first IV dose of drug X is 25 mg/L. The drug’s half-life is 3.5 hours, and it is administered every 12 hours. What will be the peak plasma concentration at steady state?
6) A patient is prescribed a new drug that needs to be infused intravenously. The drug is available as a 20mg/mL solution and is run at a flow rate of 300mg/hour. Assuming that there are 20 drops in each mL, what is the flow rate in drops per minute of the infusion?unit- drops/min
Mrs B, aged 43 years, weight 56 kg, requires a loading dose of drug B. The target plasma concentration is 18.9 mg/ L, volume of distribution is 0.5 L/ kg, the salt factor is 0.9 and bioavailability fraction is 1. What is the intravenous loading dose (LD) of Drug B in milligrams (mg)? units - mg LD = Cp desired x Vd S x F Where Cp desired is the target plasma concentration; Vd is the volume of distribution; S is the salt factor and F is the bioavailability fraction
Daisy (7 years old; 30 kg) is admitted to hospital for meningitis and requires a short intravenous infusions of cefotaxime. A dose of 50 mg/kg is recommended every 6 hours for the first 4 days. Only 2 g cefotaxime vials are available. The powder in the vials is dissolved with 4.0 mL of saline. Calculate the volume (in mL to 1 d.p.)of this solution which should be transfered to the 40mL syringe driver for a single infusion.
a physician orders 200 mcg of atropine sulfate in state and then every hour until poisoning symptoms subside. how many doses are in one 20-ml vial of atropine sulfate injection 400 mcg/ml?
Calculate drug clearance in the figure below assuming that drug dose was 4000 mg: 1000 y 400e0916 100 10 05 (25 Time thours) Plasma concentr ation (me/L)
Ex: A 70 Kg patient is to be given oubain by Lv. infusion. The drug has a half-life of 22 hours, apparent Vd 15.7liters and the desired Steady-State plasma concentration is 0.0002 mcg/ml. Assuming one-compartment kinetics, calculate 1-time required reaching 90% of Css? 3- the loading dose to attain the Css rapidly? e 10:40 /

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