10. Two men with hyperglycemia visited an endocrinologist. One patient wasdiagnoscd with Itsenko-Cushing's discase; another was diagnosed with diabetesmellitus. Explain the differentiation in these disorders. What metabolic changeswill be characteristic in these patients? For answer:a) compare the changes in carbohydrate metabolism for both patients;b) cnumcrate the metabolic changes for diabetes mellitus;c) explain which disorder causes ketoacidosis and why.LA pationtoomplainteoforedroueinoce

Cushing syndrome occurs due to an exposure to high corticosteroid levels for a long period of time…

Answered: 10. Two men with hyperglycemia visited…

Basic Clinical Laboratory Techniques 6E

6th Edition

ISBN:9781133893943

Author:ESTRIDGE

Publisher:ESTRIDGE

Chapter6: Basic Clinical Chemistry

Section6.5: Blood Glucose And Hemoglobin A1c

Problem 14RQ

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8. Ketone bodies were found in the urine of the patient with diabetes mellitus. Explain the sequence of metabolic changes resulting in ketonuria. For that answer the question and do the following tasks: a) what are the ranges of ketone bodics in blood of the healthy pcople and the patients with diabetes mellitus? b) explain the main changes in hormonal regulation of patient with diabetes mellitus; c) explain why the level of free fatty acids in the blood is clevated; d) name the pathways of lipid metabolism which becomes more active in patients with diabetes mellitus; e) draw the scheme of ketone body synthesis and oxidation.
3. A patient has got excess carbohydrate meal for the years and gain the weight. To explain this: a) draw the schemes of TAG synthesis in the liver; b) describe the transport of TAG from the liver to adipose tissue; c) describe the functions of insulin in the conversion of glucose to TAG in the liver and adipose tissue. Glucose containing Catoms was added to isolated hepatocytes inanexperiment. Ifthe glucose was added in excess, the rate of triacylglyccrol synthesis increased.
5. There is an expression: diabetes mellitus is «hunger among abundance. What metabolic changes in diabetes confirm the validity of this statement? For answer: 9.8. Metabolic Changes in Diabetes Mellitus 535 a) list the main causes of metabolic changes in IDDM; b) enumerate the tissues with the main energy sources metabolism procceding according to this type of starvation; c) name the metabolic pathways that are activated and inhibited in these tissues, and explain why; d) list the symptoms of diabetes mellitus, that reflect such metabolic changes; c) draw a diagram of one of the mctabolic pathways that is activated in the liver under these conditions and explain the consequences of such activation.
8. The adipose tissue is not only store triacylglycerols but also is active endocrine organ. Explain this function of the adipose tissuc. For that: a) explain the «clinical obesity» and possible consequences of the discase; b) name the biologically active molecules secreted by the adipose tissue; c) explain how secretion of these molecules changes with development of obesity. 9. A daily dict ofa 55-ycar-old woman, consisted ofa 500 g of carbohydrates, 100g of animal fats and 150 g of proteins, at the background of low physical activity.
3. After 12 days of starvation, a man reduced his weight by 4 kg. The doctor prescribed him biochemical blood test to analyze the level of lipids in serum blood. The results showed an elevated level of free fatty acids and triacylglycerols. Explain the results of the biochemical blood test. For that: a) name the main hormone which manages metabolism during starvation; b) draw the scheme of this hormone action on the adipose tissue; c) name the possible pathways of fatty acids usage in the liver during starvation and write down the proper schemes.
15.18) Determine whether the following statements describe insulin, glucagon, or both insulin and glucagon. a) secreted by pancreas both insulin and glucagon b) released when blood glucose concentration is high insulin c) released when blood glucose concentration is low glucagon d) immediately increases the amount of glucose entering cells insulin e) is a hormone both insulin and glucagon f) lowers blood glucose concentration insulin g) not enough is produced by individuals with type-1 diabetes insulin h) stimulates glycogen breakdown (glycogenolysis) glucagon EXPLANATION: When insulin binds to liver and muscle cell receptors, it triggers a series of events that result in the activation of an enzyme in the glycogenesis pathway and the inhibition of an enzyme in the glycogenolysis pathway. Glucagon has the opposite effect of insulin on liver cells; it accelerates glycogenolysis and suppresses glycogenesis causes a decrease in blood glucose levels • accelerated by insulin suppressed by…
Certain malignant tumors of the pancreas cause excessive production of insulin.Affected individuals exhibit shaking and trembling, weakness and fatigue, sweatingand hunger.a) What is the effect of hyperinsulinism on the metabolism of carbohydrates,amino acids, and lipids by the liver?b) What are the causes of the observed symptoms? Suggest why this condition, ifprolonged, leads to brain damage.
In people with diabetes mellitus Type 1, explain the reason for:(a) ketoacidosis, and (b) ketonuria.
Which of the following is a clinical manifestation consistent with diabetic ketoacidosis? Question 63 options: a) Glucose < 14 mmol/L b) pH > 7.51 c) Bicarbonate > 30 mmol/L d) Acetone breath
Administration of insulin decreases the blood concentration of ketone bodies in patients with diabetic ketoacidosis by which of the following mechanisms?A) Decreasing formation of ketone bodies in skeletal muscleB) Decreasing lipolysis in adipose tissueC) Increasing hepatic activity of carnitine acyltransferaseD) Increasing hepatic levels of acetyl CoAE) Increasing hepatic oxidation of ketone bodies
8. In patients after prolonged hepatitis, the ALT and AST activities were measured in the blood serum. What transaminase activity is inereased to a greater extent, and why? For the answer: a) explain the meaning of the enzyme diagnostics; b) draw the scheme of reactions catalyzed by ALT and AST; c) point out coenzyme of these reactions; describe vitamin from which this cocnzyme is derived; d) describe the biological importance of this type of reactions in amino acid metabolism; e) specify the demands which are claimed to enzymes been used in enzyme diagnostics.
A client with Type 1 diabetes mellitus is admitted to the hospital in a semi-conscious state with fever, nausea, and vomiting. The urine sample was positive for ketone bodies. Which of the following statements regarding the client is correct? Question 80 options: a) Glucagon should be administered to stimulate glycogenolysis and gluconeogenesis in the liver b) An injection of insulin will decrease ketone-body production c) The client should be started on a glucose infusion to help them regain consciousness d) The client's blood glucose level is well below 4.4 mmol/L

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