Homework Help is Here – Start Your Trial Now!
Science
Biology
1. Read the FRQ prompt below: Solid tumors are clusters of cancer cells and often contain blood vessels. When molecule B binds to the wild-type Brec protein in the plasma membrane of certain solid tumor cancer cells (Figure 1), the cancer cells express the membrane protein A and sometimes stimulate increased growth of blood vessels into the tumors. Cells with a particular mutation in the Brec gene (Brec-MUT cells) have much increased expression levels of A and stimulate greater growth of blood vessels than do cancer cells with the wild-type Brec (Brec-WT cells); the cells with the mutant Brec can trigger intracellular signaling in the absence of B. Researchers proposed that the signaling pathway modeled in Figure 1 is triggered by activation of the wild-type BrecBrec and is associated with phosphorylation and activation of kinase D, expression of A, and the ability of the cancer cells to stimulate blood vessel growth. -B Brec (Inactive) Plasma Membrane Stimulate C-P D (Inactive) C-O growth of blood vessels into tumors O-D (Active) Brec P-Kinase Kinase (Inactive) (Active) (Active) P Phosphate group Figure 1. A simplified model of the normal signaling pathway hypothesized to play a role in certain cancer cells expressing A and stimulating blood vessel growth into solid tumors 2. With a partner, summarize the NORMAL signaling pathway depicted and MUTATED signaling pathway. In your summary, break down the pathway into the three steps of signal transduction! 3. Have BOTH partners copy the summary onto a piece of paper (so that EACH partner has their summary written on their own piece of paper).

1. Read the FRQ prompt below: Solid tumors are clusters of cancer cells and often contain blood vessels. When molecule B binds to the wild-type Brec protein in the plasma membrane of certain solid tumor cancer cells (Figure 1), the cancer cells express the membrane protein A and sometimes stimulate increased growth of blood vessels into the tumors. Cells with a particular mutation in the Brec gene (Brec-MUT cells) have much increased expression levels of A and stimulate greater growth of blood vessels than do cancer cells with the wild-type Brec (Brec-WT cells); the cells with the mutant Brec can trigger intracellular signaling in the absence of B. Researchers proposed that the signaling pathway modeled in Figure 1 is triggered by activation of the wild-type BrecBrec and is associated with phosphorylation and activation of kinase D, expression of A, and the ability of the cancer cells to stimulate blood vessel growth. -B Brec (Inactive) Plasma Membrane Stimulate C-P D (Inactive) C-O growth of blood vessels into tumors O-D (Active) Brec P-Kinase Kinase (Inactive) (Active) (Active) P Phosphate group Figure 1. A simplified model of the normal signaling pathway hypothesized to play a role in certain cancer cells expressing A and stimulating blood vessel growth into solid tumors 2. With a partner, summarize the NORMAL signaling pathway depicted and MUTATED signaling pathway. In your summary, break down the pathway into the three steps of signal transduction! 3. Have BOTH partners copy the summary onto a piece of paper (so that EACH partner has their summary written on their own piece of paper).

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
See similar textbooks
icon
Related questions
Question

Describe the steps of the signal transduction pathway for the cancer cells of today's Learn About It and Try It.

Directions: 1. Read the FRQ prompt below: Solid tumors are clusters of cancer cells and often contain blood vessels. When molecule B binds to the wild-type Brec protein in the plasma membrane of certain solid tumor cancer cells (Figure 1), the cancer cells express the membrane protein A and sometimes stimulate increased growth of blood vessels into the tumors. Cells with a particular mutation in the Brec gene (Brec-MUT cells) have much increased expression levels of A and stimulate greater growth of blood vessels than do cancer cells with the wild-type Brec (Brec-WT cells); the cells with the mutant Brec can trigger intracellular signaling in the absence of B. Researchers proposed that the signaling pathway modeled in Figure 1 is triggered by activation of the wild-type BrecBrec and is associated with phosphorylation and activation of kinase D, expression of A, and the ability of the cancer cells to stimulate blood vessel growth. 2... B Brec (Inactive) Plasma Membrane Stimulate growth of blood vessels into tumors C-P D (Inactive) C-O P-D (Active) Brec P-Kinase Kinase (Inactive) (Active) (Active) P Phosphate group Figure 1. A simplified model of the normal signaling pathway hypothesized to play a role in certain cancer cells expressing A and stimulating blood vessel growth into solid tumors 2. With a partner, summarize the NORMAL signaling pathway depicted and MUTATED signaling pathway. In your summary, break down the pathway into the three steps of signal transduction! 3. Have BOTH partners copy the summary onto a piece of paper (so that EACH partner has their summary written on their own piece of paper).
Transcribed Image Text:Directions: 1. Read the FRQ prompt below: Solid tumors are clusters of cancer cells and often contain blood vessels. When molecule B binds to the wild-type Brec protein in the plasma membrane of certain solid tumor cancer cells (Figure 1), the cancer cells express the membrane protein A and sometimes stimulate increased growth of blood vessels into the tumors. Cells with a particular mutation in the Brec gene (Brec-MUT cells) have much increased expression levels of A and stimulate greater growth of blood vessels than do cancer cells with the wild-type Brec (Brec-WT cells); the cells with the mutant Brec can trigger intracellular signaling in the absence of B. Researchers proposed that the signaling pathway modeled in Figure 1 is triggered by activation of the wild-type BrecBrec and is associated with phosphorylation and activation of kinase D, expression of A, and the ability of the cancer cells to stimulate blood vessel growth. 2... B Brec (Inactive) Plasma Membrane Stimulate growth of blood vessels into tumors C-P D (Inactive) C-O P-D (Active) Brec P-Kinase Kinase (Inactive) (Active) (Active) P Phosphate group Figure 1. A simplified model of the normal signaling pathway hypothesized to play a role in certain cancer cells expressing A and stimulating blood vessel growth into solid tumors 2. With a partner, summarize the NORMAL signaling pathway depicted and MUTATED signaling pathway. In your summary, break down the pathway into the three steps of signal transduction! 3. Have BOTH partners copy the summary onto a piece of paper (so that EACH partner has their summary written on their own piece of paper).
Expert Solution
trending now

Trending now

This is a popular solution!

steps

Step by step

Solved in 2 steps

SEE SOLUTIONCheck out a sample Q&A here
Blurred answer
Knowledge Booster
Cell signaling
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.
Similar questions
  • SEE MORE QUESTIONS
Recommended textbooks for you
Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
Biology
ISBN:
9780134580999
Author:
Elaine N. Marieb, Katja N. Hoehn
Publisher:
PEARSON
Biology 2e
Biology 2e
Biology
ISBN:
9781947172517
Author:
Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:
OpenStax
Anatomy & Physiology
Anatomy & Physiology
Biology
ISBN:
9781259398629
Author:
McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:
Mcgraw Hill Education,
Molecular Biology of the Cell (Sixth Edition)
Molecular Biology of the Cell (Sixth Edition)
Biology
ISBN:
9780815344322
Author:
Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Publisher:
W. W. Norton & Company
Laboratory Manual For Human Anatomy & Physiology
Laboratory Manual For Human Anatomy & Physiology
Biology
ISBN:
9781260159363
Author:
Martin, Terry R., Prentice-craver, Cynthia
Publisher:
McGraw-Hill Publishing Co.
Inquiry Into Life (16th Edition)
Inquiry Into Life (16th Edition)
Biology
ISBN:
9781260231700
Author:
Sylvia S. Mader, Michael Windelspecht
Publisher:
McGraw Hill Education
SEE MORE TEXTBOOKS