1. Temperature: high temperature accelerate oxidation, reduction and hydrolysis reaction which lead to drug degradation 2. pH: • Acidic and alkaline pH influences the rate of decomposition of most drugs. • Many drugs are stable between pH 4 and 8. • Weekly acidic and basic drugs show good solubility when they are ionized and they also decompose faster when they are ionized. • So if the pH of a drug solution has to be adjusted to improve solubility and the resultant pH leads to instability then a way out of this tricky problem is to introduce a water miscible solvent into the product. It will increase stability by: - suppressing ionization - reducing the extreme pH required to achieve solubility - enhancing solubility and - reducing the water
6-3: This process is used by cells to manufacture _biochemical energy from nutrients into adenosine triphosphate (ATP), and then release waste products__
I will be doing this experiment to understand density of water compared to the volume of an object. D=m/v=mass/volume
Although the acetanilide and aspirin are both quite insoluble in water at room temperature, the sodium salt of aspirin is very soluble in water but insoluble in dichloromethane. Because aspirin
What is the percentage yield of the reaction of iron and copper chloride when steel wool and copper chloride dehydrate are used as reactions?
Day 1. Michael was coming home for vacation from college. When he got home he found out that
Substances A and B have an appearance of a white solid like. Substances A and B were put into a test tube and on the Bunsen burner. As a result, B melted faster than A. A was slow to melt. The reason why B melted faster than A is because it has a lower boiling point than substance A which made it melt faster. It also shows that A needs more energy than B to be broken down.
3.6.1. BAP (Benzyl amino purine) stock solution (2mg/ml): 20mg of BAP being weighed and dissolved completely in 1N NaOH to a final total volume of 10 ml with autoclaved double distilled water to obtain a stock concentration of 2mg/ml was prepared and stored in clean autoclaved vials at -4°C.
1. Place a small amount of wax from a birthday candle into a test tube. Heat gently over a burner flame until the wax melts completely; then allow
5. Zoom Out by clicking on the green arrow next to the Save button. Click on the Stockroom and then on the Clipboard and select Balloon Experiment N2. Again, set the temperature, pressure, and moles to 298 K, 1.00 atm, and 0.300 moles, respectively. You may have to click on the Units button to change some of the variables to the correct units. Repeat the experiment with this gas labeling the data link ‘Real Gas N2.’
The antacid tablets were not crushed properly, resulting in big crumbs of the tablet which will affect the dissolving process of the lab.
Panadol 6 will dissolve faster than any other panadol and all type of panadol will have increase solubility in acidic conditions
In experiment 3.11, we found out whether or not a larger amount of a liquid would get hotter when it boils. To answer this, we heated a specific amount of unknown liquid and recorded the temperature every fifteen seconds. In our scatter plot, we were able to find the boiling point of our liquid. We know that the slope of our graphs is when the liquid molecules were moving around and heating up. The plateau of our graph points is where the liquid started to evaporate and boil. This is were we found our boiling point at. Shantel and I decided that our boiling point was about 98º Celsius. If you had another slope in your graph, that was when you were simply heating the leftover gas. The histogram showed us that there were about equal amounts of data in the higher temperature (about 95º Celsius) bins for both 20mL of liquid and 10mL of liquid. Also, in the lower temperature bins (75º to 80º Celsius) there was about equal amount of data for 20mL of liquid and 10mL of liquid. There was 7 pieces of data for 10mL of liquid in the lower bins, and 6 pieces of data for 20mL of liquid. If a larger amount of liquid did have a higher boiling point, the clusters would be organized by volumes or amount. For example, all of the 20mL pieces of data would be in the higher temperature bins, and all of the 10mL pieces of data would be in the lower temperature bins or flipped. Rather, the bins were clustered by identity. The boiling point is a characteristic property.
The purpose of this lab was to investigate the amount of sugar in carbonated beverages by using the density of solutions, and also to create a standard curve with the percent sugar from sugar solutions to find the percent sugar of flat
Alka-Seltzer contains both baking soda (NaHCO3) and citric acid (H3C6H5O7). The reaction between the bicarbonate ion and citric acid produces water, carbon dioxide, and the citrate ion. Equation 1 shows the balanced equation for the reaction, which can be expressed by, C_6 H_8 O_7 (aq)+ 3NaHCO_3 (aq)→ 3H_2 O(l) + 3CO_2 (g) + Na_3 C_6 H_5 O_7 (aq) (1)
Patterson et al. used three poorly water soluble drugs (carbamazepine, dipyridamole and indomethacin) with a polymer polyvinyl pyrrolidone K30 (PVP K30) at a 1:2 drug polymer ratio to prepare glass solutions of the drugs. The glass solution was referring to an amorphous solid in which the solute will disperse in the solid solvent on a molecular level. (Patterson et al., 2007).