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Ap Chemistry Lab

Satisfactory Essays

1. Temperature: high temperature accelerate oxidation, reduction and hydrolysis reaction which lead to drug degradation 2. pH: • Acidic and alkaline pH influences the rate of decomposition of most drugs. • Many drugs are stable between pH 4 and 8. • Weekly acidic and basic drugs show good solubility when they are ionized and they also decompose faster when they are ionized. • So if the pH of a drug solution has to be adjusted to improve solubility and the resultant pH leads to instability then a way out of this tricky problem is to introduce a water miscible solvent into the product. It will increase stability by: - suppressing ionization - reducing the extreme pH required to achieve solubility - enhancing solubility and - reducing the water

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