Match enzyme name to (substrate, product) pair. Acyl-CoA dehydrogenase beta-Ketothiolase 3-Hydroxacyl-CoA dehydrogenase Carnitine acyltransferase I Enoyl-CoA hydratase Hormone-sensitive lipase Delta-3-Enoyl-CoA isomerase Glycerolphosphate dehydrogenase Acyl-CoA synthetase Delta-2,4-Dienoyl-CoA reductase (Glycerol 3-phosphate, NADH) (Butyryl-CoA, FADH) (Water, 3-Hydroxyacyl-CoA) (NADPH, Delta-3-enoyl-CoA) (Acyl-CoA, Acyl-carnitine) (ATP. Acyl-CoA) (Delta-3-Enoyl-CoA, Delta-2-Enoyl-CoA) (NAD+, 3-Ketoacyl-CoA) (3-Ketoacyl-CoA, Acetyl-CoA) v V

Match enzyme name to (substrate, product) pair. Acyl-CoA dehydrogenase beta-Ketothiolase 3-Hydroxacyl-CoA dehydrogenase Carnitine acyltransferase I Enoyl-CoA hydratase Hormone-sensitive lipase Delta-3-Enoyl-CoA isomerase Glycerolphosphate dehydrogenase Acyl-CoA synthetase Delta-2,4-Dienoyl-CoA reductase (Glycerol 3-phosphate, NADH) (Butyryl-CoA, FADH) (Water, 3-Hydroxyacyl-CoA) (NADPH, Delta-3-enoyl-CoA) (Acyl-CoA, Acyl-carnitine) (ATP. Acyl-CoA) (Delta-3-Enoyl-CoA, Delta-2-Enoyl-CoA) (NAD+, 3-Ketoacyl-CoA) (3-Ketoacyl-CoA, Acetyl-CoA) v V

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter19: The Tricarboxylic Acid Cycle

Section: Chapter Questions

Problem 22P: Study Figure 19.18 and decide which of the following statements is false. Pyruvate dehydrogenase is...

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Study Figure 19.18 and decide which of the following statements is false. Pyruvate dehydrogenase is inhibited byÂ· NIADH. Pyruvate dehydrogenase is inhibited by AÎ¤Î¡. Citrate synthase is inhibited by NADH. Succinyl-CoA activates citrate synthase. Acetyl-CoA activates pyruvate carboxylase.
Step 2 of B-oxidation involves a reaction with chemistry characterized as a dehydration. B-Oxidation is shown below. H HO || || C-C-S – CoA FAD но R-CH2- C Acyl-CoA dehydrogenase H-C-C -S- CoA Acetyl-CoA Fatty acyl-CoA H FADH2 - CH2 - -c-S- CoA R- Thiolase Fatty acyl-CoA shortened by two carbons COA-SH H. он Successive cycles R-CH2-C-C- -C-S- CoA R– CH2 C=C-C-S-CoA H B-Ketoacyl-Co.A trans-A²Enoyl-CoA NADH + H* H,0 H H L-Hydroxyacyl-CoA dehydrogenase Enoyl-CoA hydratase R- CH,-c-c-C- S-CoA Но H NAD+ L-B-Hydroxyacyl-CoA True O False
Using the list of enzymes given below, provide all chemical structures and reactions for complete metabolism of the fatty acids 8:0, 18:145 and 12:247,10. It is unnecessary to repeat a reaction once it has been drawn out previously. Refer to the repeated reaction by group and number. Use the next pages if necessary and clearly identify which fatty acid is being metabolized.
Which enzyme is used for both the synthesis and breakdown of acetoacetate? thiolase O HMG-CoA synthase OB-hydroxybutyrate dehydrogenase O B-Ketoacyl-CoA transferase
Identify a pathway for utilization of the four carbons of acetoacetate in cholesterol biosynthesis. Carry your pathway as far as the rate-determining reaction in cholesterol biosynthesis. Drag the appropriate labels to their respective targets. succinyl-CoA succinate acetyl-CoA CoA-SH acetoacetyl-CoA HMG-CoA 2NADP 2NADPH+ 2H acetoacetate K UHL return to a mevalonate + CoA-SH
C-CH2 + H* CO, + CH,-C-S-COA S-COA Malonyl-CoA Acetyl-CoA Hydrolase Transferase Lyase Ligase
What enzyme(s) is/are specifically required for the oxidation of a Aeven monounsaturated fatty acid? (select all that apply) O Methylmalonyl CoA Mutase O enoyl-CoA Hydratase 43-enoyl-CoA isomerase Thiolase 2,4-Dienoyl-CoA Reductase OPropionyl-CoA carboxylase
4. Identify: for nos. 1-5: Name of the missing metabolite in the pathway 6-10: Enzyme that catalyzed the reaction 11-15: Reaction involved 5 FAD 10 -FADH₂ trans-2-En oyl-CoA 15 H₂O 3-Hyroxya cyl-CoA NAD+ NADH+H+ beta-Ketoacyl-CoA COASH Acetyl-CoA Acyl-CoA (2 C Atoms Shorter) Malate Fumarate Glucose 6 Glucose-6-phosphate 11 Fructose-6-phosphate Phoshphoenolpyruvate Succinate 12 Acetyl ČOA 13 7 Citrate 3 Lactate 14 Isocitrate 8 a-ketoglutarate
What is the rate-limiting step in the synthesis of acetyl CoA? oxidation regeneration of lipoamide decarboxylation transfer to lipoamide transfer to CoA
Discuss the metabolic control for HMG CoA reductase synthesis and activity
Arrange the steps of breakdown of oleic acid (pictured below) in the correct order. 1 2 3 4 5 activation by acyl-CoAsynthe ✓ [Choose ] one cycle ofß-oxidationbeginning at the enoyl-CoAhydratasestep three cycles ofẞ-oxidation five cycles ofß-oxidation activation by acyl-CoAsynthetase enoyl-CoAisomeraseactivity enoyl-CoAisomeraseactivity V one cycle ofß-oxidationbegini V five cycles ofß-oxidation OH
Identify the components of animal fatty acid synthase (FAS). ☐acyl-CoA dehydrogenase B-ketoacyl synthase ☐acyl-CoA synthetase B-hydroxyacyl-ACP dehydratase malonyl-CoA-acetyl-CoA-ACP transacylase (MAT) B-enoyl-ACP reductase