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- Distinguish between a. neutrophil and macrophage b. cytotoxic T cell and natural killer cell c. effector cell and memory cell d. antigen and antibodyMatch the immunity concepts: __________ inflammation __________ antibody secretion __________ phagocyte __________ immunological memory __________ vaccination __________ allergy a. neutrophil b. plasma cell c. nonspecific response d. purposely causing memory cell production e. basis of secondary immune response f. nonprotective immune responseMatch the antibody classes with their characteristics: IgM IgG IgA IgE IgD Most efficient for agglutination Most abundant in blood; easily penetrates tissue spaces Most abundant in mucus; traps pathogens in mucus Located on the surface of B cells; trace amounts can be found in serum Least abundant; helps stimulate inflammatory response
- All of the following are true of antigen-presenting cells (APCs) EXCEPT: which option below is the answer? None of the other four answers (All are true statements about APCs) They can interact directly with lymphocytes They include macrophages and dendritic cells APCs by themselves cannot distinguish between different microbial antigens, remember them later, or respond specifically to them They are non-specific cells and they play no role in activating or triggering specific immune responsesWhich of the following statements is NOT correct? Group of answer choices -Natural killer cells are cytolytic lymphocytes that mediate ADCC -Neutrophils carry out phagocytosis of C3b-tagged particles -Macrophages carry out phagocytosis of C3b-tagged particles -Mast cells produce granules containing the cytotoxin perforin -B lymphocytes express a receptor for complement proteinsExplain the process of B cell clonal selection (remember to mention the cells originated in this process with their functions).
- Drop each label into the appropriate box, indicating which class of immunoglobulin is being described. Some labels are used more than once. Functions in B cell activation In exocrine gland secretions t IgE Crosses placenta Defends against bacteria and viruses On surface of most B lymphocytes Defends against bacteria, viruses, and toxins IgA IgM In breast milk, tears, nasal fluid, gastric juice, and urine Causes agglutination in transfusion reactions Promotes inflammation and allergic reactions IgG IgD Activates complement proteinsGenerally, polysaccharides are not good antigens, because B cells that recognize them cannot get T-cell help. But for some pathogens, such as Streptococcus pneumoniae opsonization by antibodies that bind the thick polysaccharide "capsule" layer surrounding the bacteria is the major mechanism of clearing the infection. As expected, a pure polysaccharide vaccine is not terribly effective, but much better immunity is achieved by vaccinating with a polysaccharide covalently linked "conjugated" to an unrelated protein. Explain how this conjugate vaccine allows B cells capable of making anti-polysaccharide antibodies.What scenario best describes an autoimmune reaction? Group of answer choices The destruction of donated red blood cells by the recipient’s immune system The production of antibodies against Streptococcus pyogenes antigen resulting in cross-reaction against an antigen found on heart valves The activation of Mast cells by pollen The production of antibodies against Streptococcus pyogenes resulting in the deposit of antigen-antibodies in the kidney leading to glomerulonephritis
- Strep throat is commonly caused by group A Streptococcus bacteria. A common symptom of strep throat is the presence of swollen lymph nodes in the neck. This symptom usually peaks about 2–4 days after the onset of the infection, and is due to: Damage to the pharyngeal epithelium by the bacteria Release of bacterial PAMPs leading to inflammatory cytokine production Trapping and activation of antigen-specific lymphocytes in the lymph nodes of the neck Recruitment of neutrophils to the lymph nodes of the neck Recruitment of circulating macrophages to the lymph nodes of the neckSketch a B cell antigen receptor. Label the V and C regions of the light and heavy chains. Label the antigenbinding sites, disulfide bridges, and transmembrane region. Where are these features located relative to the V and C regions?According to the clonal selection theory, all immunoglobulin molecules in an individual B cell have the same antigenic specificity. Explain why the presence of IgM and IgD on the same B cell does not violate the nonspecificity implied by clonal selection.