der(X) der(22) 22 der(X) 22 der(X) 22 First row is mother, second row is first daughter, third row is second daughter. Phenotype in first daughter was much more severe than second daughter. Give best explanation: O Inactivation in second daughter spread to the extra chromosome 22 segment O Having 45 chromosomes always gives a more severe phenotype than 46 chromosomes O Pattern of inactivation in other tissues, including brain might differ, giving functional 22q monosomy The presence of the third X in the second daughter decreases effect of genetic abnormality First daughter has a Turner-like syndrome, which explains severity ..---------- --------- -------------- 7------- L------------- ---------- . Ix ------

Biology: The Unity and Diversity of Life (MindTap Course List)
15th Edition
ISBN:9781337408332
Author:Cecie Starr, Ralph Taggart, Christine Evers, Lisa Starr
Publisher:Cecie Starr, Ralph Taggart, Christine Evers, Lisa Starr
Chapter14: Chromosomes And Human Inheritance
Section: Chapter Questions
Problem 5GP: Human females have two X chromosomes (XX); males have one X and one Y chromosome (XY). a. With...
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der(X) der(22)
22
der(X)
22
der(X)
22
First row is mother, second row is first daughter, third row is second daughter.
Phenotype in first daughter was much more severe than second daughter.
Give best explanation:
O Inactivation in second daughter spread to the extra chromosome 22
segment
O Having 45 chromosomes always gives a more severe phenotype than 46
chromosomes
Pattern of inactivation in other tissues, including brain might differ, giving
functional 22q monosomy
O The presence of the third X in the second daughter decreases effect of
genetic abnormality
O irst daughter has a Turner-like syndrome, which explains severity
---------
----------
----------
------------
---------.
-------------
------------
OO ix
Transcribed Image Text:of der(X) der(22) 22 der(X) 22 der(X) 22 First row is mother, second row is first daughter, third row is second daughter. Phenotype in first daughter was much more severe than second daughter. Give best explanation: O Inactivation in second daughter spread to the extra chromosome 22 segment O Having 45 chromosomes always gives a more severe phenotype than 46 chromosomes Pattern of inactivation in other tissues, including brain might differ, giving functional 22q monosomy O The presence of the third X in the second daughter decreases effect of genetic abnormality O irst daughter has a Turner-like syndrome, which explains severity --------- ---------- ---------- ------------ ---------. ------------- ------------ OO ix
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