Concepts of Genetics (12th Edition)
Concepts of Genetics (12th Edition)
12th Edition
ISBN: 9780134604718
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino, Darrell Killian
Publisher: PEARSON
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Chapter 5, Problem 1CS

In a family with one autistic child the risk for another affected child is approximately 25 percent. This is the same level of risk that a couple who are each heterozygous for a recessive allele will have an affected child. What are the similarities and differences in these two situations?

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Summary Introduction

To determine: The similarities and differences between the cases-one autistic child in family raising the 25 % risk for another to develop autism and the heterozygous couple having an affected child.

Introduction: Autism is a severe developmental disorder in which the individual has impaired communication. The person faces challenges with social interaction, has obsessive interests and repetitive behaviors. The family which has one autistic child, the risk for another affected child gets raised by 25%. This is considered the same level of risk that a couple, both heterozygous for the recessive allele would have as they give rise to an affected child.

Explanation of Solution

The similarity between the two situations is that both of them give rise to autism affected individual. The development of autism can be both genetic and environmental. In the case, where the presence of one autistic child in the family raises the risk by 25% for the second child to be affected with the disease, shows the environmental causes of the disorder. On the other hand, the presence of two heterozygous (for recessive allele) parents to produce an affected child, shows the genetic cause of disease.

The differences between the two situations are as follows:

No.CharacteristicsA family with already an autistic childA couple heterozygous for recessive allele
1.Cause of diseaseThe probability of the second child to have the disease shows the non-genetic cause of disease.The probability of a child to develop autism from heterozygous parents shows a genetic form of the disease.
2.Proposed mechanism for development of diseaseThe nongenetic cause of autism is neuroinflammation, where there is an abnormality in the white matter. The white matter acts as a wiring tissue for connecting areas of the brain.The genetic cause of autism occurs when both the parents have one recessive allele for the disease. As a result, when an individual has the presence of both the recessive alleles, autism is developed.

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Chapter 5 Solutions

Concepts of Genetics (12th Edition)

Ch. 5 - Why are double-crossover events expected less...Ch. 5 - What is the proposed basis for positive...Ch. 5 - What two essential criteria must be met in order...Ch. 5 - The genes dumpy (dp), clot (cl), and apterous (ap)...Ch. 5 - Colored aleurone in the kernels of com is due to...Ch. 5 - In the cross shown here, involving two linked...Ch. 5 - In a series of two-point mapping crosses involving...Ch. 5 - Two different female Drosophila were isolated,...Ch. 5 - In Drosophila, a cross was made between femalesall...Ch. 5 - Another cross in Drosophila involved the...Ch. 5 - In Drosophila, Dichaete (D) is a mutation on...Ch. 5 - Drosophila females homozygous for the third...Ch. 5 - In Drosophila, two mutations, Stubble (Sb) and...Ch. 5 - If the cross described in Problem 18 were made,...Ch. 5 - Are mitotic recombinations and sister chromatid...Ch. 5 - What possible conclusions can be drawn from the...Ch. 5 - An organism of the genotype AaBbCc was testcrossed...Ch. 5 - Based on our discussion of the potential...Ch. 5 - Traditional gene mapping has been applied...Ch. 5 - DNA markers have greatly enhanced the mapping of...Ch. 5 - In a certain plant, fruit is either red or yellow,...Ch. 5 - Two plants in a cross were each heterozygous for...Ch. 5 - A number of humanmouse somatic cell hybrid clones...Ch. 5 - A female of genotype produces 100 meiotic tetrads....Ch. 5 - In laboratory class, a genetics student was...Ch. 5 - Drosophila melanogaster has one pair of sex...Ch. 5 - In Drosophila, a female fly is heterozygous for...Ch. 5 - The gene controlling the Xg blood group alleles...Ch. 5 - Prob. 34ESP
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