Read the passage first then please answer in full details: In 1935, the daughter of Gerhard Domagk, a doctor at I. G. Farbenindustrie, aGerman dye manufacturing company, contracted a streptococcal infection from apin prick. As his daughter was nearly dying, Domagk took the risk of giving heran oral dose of a dye called Protonsil. This dye had been shown to inhibit thegrowth of streptococci in mice. Very soon the little girl recovered. Domagk'sgamble not only saved his daughter's life, but it also sparked a new andimpressively productive phase in modern chemotherapy.The following year, in 1936, Ernest Fourneau of the Pasteur Institute in Parisdemonstrated that Protonsi! breaks down in the human body to producesulfan:lamide. He also demonstrated that sulfanilamide is the active agent againststreptococci. Fourneau's announcement of this result started the search for otherchemicals related to sulfanilamide that might have even better chemotherapeuticeffects. Thousands of chemical variations were played on the sulfanilamidetheme: the structure of sulfanilamide was varied in almost every imaginable way.Now, after that long story, here's the problem that you're supposed to work on.The structure of Protonsil is given below.NH2H2N-N= N-NH2Protonsil You can see that it is an azo dye, can't you? Knowing that an azo compoundis produced for the coupling of a diazonium ion with a strongly activatedaromatic compound, can you suggest the starting materials for thepreparation of Protonsil? And from here, I'm sure you can make aneducated guess on what the structure of sulfanilamide is.

Being an antibacterial drug, the Prontosil also called as rubiazol contains the sulfonamide group.…

You can see that it is an azo dye, can't you? Knowing that an azo compound is produced for the coupling of a diazonium ion with a strongly activated aromatic compound, can you suggest the starting materials for the preparation of Protonsil? And from here, I'm sure you can make an educated guess on what the structure of sulfanilamide is.

You can see that it is an azo dye, can't you? Knowing that an azo compound is produced for the coupling of a diazonium ion with a strongly activated aromatic compound, can you suggest the starting materials for the preparation of Protonsil? And from here, I'm sure you can make an educated guess on what the structure of sulfanilamide is.

Introduction to General, Organic and Biochemistry

11th Edition

ISBN:9781285869759

Author:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres

Publisher:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres

Chapter31: Immunochemistry

Section: Chapter Questions

Problem 31.72P

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