You are interested in how CAMP-dependent protein kinase A (PKA) functions to affect learning and menory, and you decide to study its function in the brain. It is known that, in the cells you are studying, PKA is an effecter protein of a GPCR signaling pathway that stimulates adenylyl cyclase. It is also known that activated PKA phosphorylates the transcriptional regulator called Nerd that then activated transcription of the gene Brainy. Explain the effect of mutation in the gene that encodes CAMP phosphodiesterase that makes the phosphodiesterase enzyme inactive.

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
icon
Related questions
Question
Please help me with this question immediately within an hour
QUESTION 4
You are interested in how CAMP-dependent protein kinase A (PKA) functions to affect learning and memory, and
you decide to study its function in the brain. It is known that, in the cells you are studying, PKA is an effecter protein
of a GPCR signaling pathway that stimulates adenylyl cyclase. It is also known that activated PKA phosphorylates
the transcriptional regulator called Nerd that then activated transcription of the gene Brainy.
Explain the effect of mutation in the gene that encodes CAMP phosphodiesterase that makes the
phosphodiesterase enzyme inactive.
Transcribed Image Text:QUESTION 4 You are interested in how CAMP-dependent protein kinase A (PKA) functions to affect learning and memory, and you decide to study its function in the brain. It is known that, in the cells you are studying, PKA is an effecter protein of a GPCR signaling pathway that stimulates adenylyl cyclase. It is also known that activated PKA phosphorylates the transcriptional regulator called Nerd that then activated transcription of the gene Brainy. Explain the effect of mutation in the gene that encodes CAMP phosphodiesterase that makes the phosphodiesterase enzyme inactive.
Expert Solution
trending now

Trending now

This is a popular solution!

steps

Step by step

Solved in 3 steps

Blurred answer
Knowledge Booster
Medical terminologies
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biochemistry and related others by exploring similar questions and additional content below.
Similar questions
  • SEE MORE QUESTIONS
Recommended textbooks for you
Biochemistry
Biochemistry
Biochemistry
ISBN:
9781319114671
Author:
Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:
W. H. Freeman
Lehninger Principles of Biochemistry
Lehninger Principles of Biochemistry
Biochemistry
ISBN:
9781464126116
Author:
David L. Nelson, Michael M. Cox
Publisher:
W. H. Freeman
Fundamentals of Biochemistry: Life at the Molecul…
Fundamentals of Biochemistry: Life at the Molecul…
Biochemistry
ISBN:
9781118918401
Author:
Donald Voet, Judith G. Voet, Charlotte W. Pratt
Publisher:
WILEY
Biochemistry
Biochemistry
Biochemistry
ISBN:
9781305961135
Author:
Mary K. Campbell, Shawn O. Farrell, Owen M. McDougal
Publisher:
Cengage Learning
Biochemistry
Biochemistry
Biochemistry
ISBN:
9781305577206
Author:
Reginald H. Garrett, Charles M. Grisham
Publisher:
Cengage Learning
Fundamentals of General, Organic, and Biological …
Fundamentals of General, Organic, and Biological …
Biochemistry
ISBN:
9780134015187
Author:
John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. Peterson
Publisher:
PEARSON