With detailed accounts of their various forms, explain any three of the following chromosomal aberrations: a) Deletions b) Duplications c) Translocations d)Inversion
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With detailed accounts of their various forms, explain any three of the following chromosomal aberrations:
a) Deletions
b) Duplications
c) Translocations
d)Inversion
Step by step
Solved in 2 steps
- Which type(s) of chromosomal aberrations result from chromosomal breaks on different chromosomes? Assume that a heterozygote for the aberration is viable. Select all correct answers. A.)Robertsonian translocation B.)reciprocal translocation C.)tandem duplication D.)paracentric inversion E.)pericentric inversion F.)large deletionAnswer the following questions: A) Why the extension cannot be 3´---5´ and why it has to be 5´------3´? B) What is a gene?During meiotic prophase in a eukaryotic cell, Spo11 initiates recombination by causing a double-strand break in DNA between Gene A and Gene B on one sister chromatid. Which of these events will occur prior to formation of a Holliday junction? A) A heteroduplex forms due to pairing of Gene A and Gene B. B) Resolvase cuts all four chromatids. C) Spo11 causes a double-strand break in a nonsister chromatid. D) Strand invasion causes one strand of the uncut chromatid to form a D loop. E) Branch migration lengthens the heteroduplex region to include Gene A and Gene
- 1) What type of chromosome abnormality does the father have? a)Duplication b)Inversion c)Deletion d)Translocation 2) Why does the father have a normal phenotype? a) Because the translocation was reciprocal. b) Because he has one wild-type copy of each chromosome. c) Because the translocation occurred only in the father's gametes. d) Because no genes are missing.13) Use the image below of the X and Y sex chromosomes of a human to answer the following question. Which of the following statements is true? A) This person is a female with Haemophilia. B) This person is a male with Ocular Albinism. C) This person is a female with Ocular Albinism. D) This person is a male with no sex linked genetic disorders. X Ocular albinism Duchenne muscular dystrophy Androgen insensitivity Severe combined immunodeficiency Haemophilia Colour blindness Y DOLD SRY Sex determination AZF Sperm developmentExplain two ways that a chromosomal rearrangement can cause a position effect.
- Which of the following is NOT an example of a spontaneous mutation? A) errors in replication of DNA polymerase B) ALL of these are examples of spontaneous mutations C) covalent alteration of DNA by chemical products of fatty acid metabolism D) incorporation of a nucleotide analog during DNA synthesis E) failure to correct an apurinic site F) nondisjunction during meiosisMatch the pictures of the small-scale chromosome changes to the terms. A) translocation B) deletion C) inversion D) duplicationWhich of the following chromosomal events can result in Down’s Syndrome offspring? a) Primary nondisjunction of chromosome 21 b) Secondary nondisjunction of chromosome 21 c) A parent with a Robertsonian Translocation of 21 to 14 d) All of the above
- Which of these chromosomal rearrangements will result in formation of a loop during prophase I if an organism is heterozygous for the chromosomal aberration? Select all correct answers. A.)reciprocal translocation B.)tandem duplication C.)Robertsonian translocation D.)pericentric inversion E.)paracentric inversionSelect the statements below that are TRUE. Select 4 correct answer(s) Question 14 options: A) Mutations are induced to occur in response to a selective pressure. B) Crossover suppression occurs when no recombinant progeny are observed between two genes located within a homozygous paracentric inversion. C) The ends of each chromosome are replicated by an RNA-protein complex called telomerase. D) When a mismatched base pair occurs during DNA replication, mismatch repair corrects the mismatch by replacing the nucleotide on the template strand. E) Mutations occur spontaneously and so may be pre-existing in a population when a selective pressure arises. F) When two genes are linked, the frequency of recombinant types exceeds the frequency of parental types. G) The choice…a) What is the chromosomal abnormality associated with Fragile-X Syndrome? b) What is the phenotype associated with this disorder? c) How is this trait inherited?