Which of the following will increase the rate of transcription? a. Activation of a transcriptional repressor b. Inhibition of a transcriptional activator c. Histone methylation leading to chromatin compaction d. Removal of RNA polymerase
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- Which of the following may produce more than one functional protein from an mRNA transcript?a. chromatin condensation b. transcriptional regulation c. epigeneticsd. alternative mRNA processingWhich of the following is an example of chromatin modification that stimulates gene expression? Group of answer choices A. alternative exon splicing b. microRNA binding to mRNA c. DNA methylation D. histone acetylationDefine the following terms: a. promoter b. consensus sequence c. operon d. chromatin-remodeling complex e. general transcription factors
- What factors are utilized by the cell in order to recognize the stop codon and disassemble the translation machinery? A. elongation factors B. release factors C. transcription factors D. initiation factors E. mRNA factorsChoose all items that regulate the transcription of mRNAs.Group of answer choices A. Transcription factor proteins B. Intron sequences C.. DNA promoter sequences D. DNA enhancer regions E. Exon sequencesIn eukaryotes, chromatin remodeling plays an important role is gene regulation. This is because a. repositioning of the nucleosomes makes DNA accessible to transcription regulatory proteins b. the nucleosomes contain important regulatory regions c. chromatin remodeling activates gene expression d. chromatin remodeling represses gene expression
- What is the name of the process that adds a modified guanosine nucleotide to the 5’ phosphates of pre-mRNAs in eukaryotes? a. splicing b. polyadenylation c. capping d. nuclear export e. photophosphorylationWhich of the following will lead to a decrease in transcription of a gene? A. Increase in histone acetyltransferases. B. Decrease in CpG methylation of promoter. C. Increase in histone deacetylases. D. Decrease in DNA methyltransferases.Which of the following mechanisms is an example of post-transcriptional gene regulation? A. binding of a repressor protein to an operon B. alternative splicing of exons in an RNA transcript C. acetylation of histones in chromatin D. methylation of specific regions of DNA
- A researcher found that she could increase phosphorylation of amino acids adjacent to methylated amino acids in histone tails. What would she see? Select one: O a. inactivation of the selected genes O b. decreased binding of transcription factors O c. decreased chromatin condensation O d. increased chromatin condensationCancer cells removed from a patient's tumor have increased gene expression of several hundred genes (including many cancer-causing genes). Scientists determine that the histones from the cancer cells have an overall/average lower affinity for DNA than histones from normal control cells. Which drug is most likely to help treat this patient's cancer? a. An inhibitor for HMT (histone methyltransferases) b. An inhibitor for HDM (histone demethylases) c. An inhibitor for HDACs (histone deacetylases) d. An inhibitor for HATs (histone acetyltransferase)Which statement/s is/are TRUE about transcription?A. During transcription, DNA polymerase binds to RNA and separates the DNA strands.B. RNA polymerase uses one strand of DNA as a template to assemble nucleotides into a strand of RNA.C. RNA polymerase binds only to DNA promoters, which have specific base sequences.D. Promoters are signals in RNA that indicate to RNA polymerase where to begin transcription.E. Transcription occurs in the 3’ to 5’ direction with respect to the growing mRNA strand.