Which of the following specifically explains why glucose uptake into intestinal cells happens in only one direction. The Na+/Glucose transporter has a binding affinity for both Na+ and Glucose. The Na+/Glucose transporter will only undergo a conformational change when both Na+ and glucose are bound. Na+ ions are always present at higher concentrations OUTSIDE of the intestinal cells. Na+ ions are always present at higher concentrations INSIDE of the intestinal cells.
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- Which of the following statements best describes the absorption of glucose? Absorption of glucose requires digestion by aminopeptidases on absorptive epithelial microvilli before absorption of the carbohydrate smaller units such as glucose. Absorption of glucose requires an electrochemical gradient of high extracellular K+ set up by primary active transport. Absorption of glucose occurs at villi and crypts mainly in the duodenum where amylases break down carbohydrates into glucose. Absorption of glucose occurs at the transporting epithelia in the small intestine and is a secondary active transport that requires a Na+gradientIf a mutation in a sodium channel in an Intestinal epithelial cell caused a marked decrease In the concentration gradient of sodium across the plasma membrane, which of the following would you expect to observe? a decrease in Na/K ATPase activity. an increase in the movement of glucose across the basolateral membrane to the extracellular space an increase in sodium/glucose co-transport into the cell across the apical membrane a decrease in cytoplasmic glucose concentrationTransport of glucose across the basolateral membrane of intestinal epithelial cells and into the vascular system requires which of the following conditions to occur? Select one: a. Sodium concentration on the inside of the epithelial cell is equal to that outside the basolateral membrane b. Sodium concentration is higher on the inside of the epithelial cell than on the outside of the basolateral membrane c. Sodium concentration inside the epithelial cell is lower than sodium concentration in the intestinal lumen d. Sodium concentration inside the epithelial cell is higher than that sodium concentration in the intestinal lumen
- A chemical called ouabain inhibits the Na/K ATPase (the sodium-potassium pump). What would happen to glucose concentrations in the extracellular fluid (not the gut lumen) after exposure to ouabain, and why? Ouabain would cause intracellular sodium levels to rise, which would reduce the active transport of glucose from the gut, thereby decreasing glucose in the extracellular fluid. Ouabain would cause extracellular sodium levels to rise, which would reduce the active transport of glucose from the gut, thereby decreasing glucose in the extracellular fluid. Ouabain would cause intracellular sodium levels to rise, which would reduce the active transport of glucose from the cell to the extracellular fluid. Ouabain would cause intracellular sodium levels to rise, which would enhance the active transport of glucose from the gut, thereby increasing glucose in the extracellular fluid.Digoxin, a toxin derived from the foxglove (shown), can be used to treat heart disorders such as atrial fibrillation. Digoxin’s mechanism of action is to inhibit the Na+/K+ ATPase. Which of the following is the most likely side effect of Digoxin treatment? Failure to transport glucose into cells during an extended fast Failure to transport glucose into cells after after eating a large meal Enhanced response of muscle cells to Acetylcholine Failure to transport Cl- out of the cell using direct active transportWhich of the following contain a correct first statement and an incorrect second statement? Beta- and gamma-subunits of the G-proteins activates adenylyl cyclase. Phospholipase C is a membrane-bound enzyme that cleaves phospholipids bound to the membrane. Polyols are highly oxidized molecules which makes them impermeable to the intestinal lining. Increasing heat of saccharin solution renders it to degradation. Intestinal microbiota utilizes reduced carbohydrate sweeteners resulting to energy production. Dextrose is a sugar that rotates the plane of polarized light in a counterclockwise manner. All natural sweeteners are nutritive. Theory of sweetness provides information on the interaction of the "sweet molecule" and its corresponding receptor.
- Carbonic anhydrase is strongly inhibited by the drug acetazolamide, which is used as a diuretic (i.e., to increase the production of urine) and to lower excessively high pressure in the eye (due to accumulation of intraocular fluid) in glaucoma. Carbonic anhydrase plays an important role in these and other secretory processes because it participates in regulatingthe pH and bicarbonate content of several body fluids. The experimental curve of initial reaction velocity (as percentage of Vmax ) versus [S] for the carbonic anhydrase reaction is illustrated below (upper curve). When the experiment is repeated in the presence of acetazolamide, the lower curve is obtained. From an inspection of the curves and your knowledge of the kinetic properties of competitive and mixed enzyme inhibitors, determinethe nature of the inhibition by acetazolamide. Explain your reasoning.A patient is on a drug for a long time ("LKM A"). When inserting "LKM B", a drug interaction occurs. Which of the following alternatives describes a drug interaction where the levels of free "LKM A" in the blood are expected to increase? Select an alternative: CYP enzyme inhibition Inhibition of uptake transporter for "LKM A" in the gastrointestinaltract Increased secretion of "LKM A" in the gastrointestinal tract CYP enzyme inductionComplex bindingWhich is not a type of endocytotic vesicular transport? a. engulfment of microorganismsb. nutrient absorption of intestinal cellsc. neurotransmitter released. insulin uptakee. none of the above
- O Att Intestinal epithelial cells pump glucose into the cell against its concentration gradient using the Nat-glucose symporter. Recall that the Nat concentration is significantly higher outside the cell than inside the cell. The symporter couples the "downhill" transport of two Nat ions into the cell to the "uphill" transport of glucose into the cell. If the Nat concentration outside the cell ([Na lout) is 161 mM and that inside the cell ([Na* Jm) is 17.0 mM, and the cell potential is -50.0 mV (inside negative), calculate the maximum energy available for pumping a mole of glucose into the cell. Assume the temperature is 37 °C. What is the maximum ratio of (glucose] to [glucoselout 10.62 kJ AG gluc mol that could theoretically be produced if the energy Incorrect coupling were 100% efficient? O 1.13 8.24 3800 2.6 x 10 Incorrectwhat type of glucose transport protein is found in pancreatic beta cells? SGLUT-1 GLUT-2 GLUT-3 GLUT-4 GLUT-5Leptin inhibits eating and is secreted in amounts in direct proportion to body fat. Moreover, obese people have normal amounts of leptin and leptin receptor. Why, then, do people become obese?