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- Equalizing the Expression of X Chromosome Genes in Males and Females Males have only one X chromosome and therefore only one copy of all genes on the X chromosome. Each gene is directly expressed, thus providing the basis of hemizygosity in males. Females have two X chromosomes, but one is always inactivated. Therefore, females, like males, have only one functional copy of all the genes on the X chromosome. Again, each gene must be directly expressed. Why, then, are females not considered hemizygous, and why are they not afflicted with sex-linked recessive diseases as often as males are?Which of the following small GTP-binding proteins does NOT play a role in cell migration during chemotaxis? O Cap Z Rho Cdc42 O All of the listed GTPases play a role in cell migration O Rac ◆ PreviousWhich of the following could be classified as an oncogene? None are possible oncogenes A mutant of MAP kinase that was active with or without being phosphorylated All are possible oncogenes A mutant of MEK with significantly reduced enzyme activity A mutant cAMP phosphodiesterase that made it super-active
- What is the abbreviated name of the human gene that contains the following sequence CAGATTGTGAAGAGGTCTCTTGA? ATR HBB XPA FGFR3 IDS XRCC1 p53 F8 APC ERCC3Which THREE statements are true about targetting proteins to the nudieus? Aln the cytoplasm, a protein with an appropriate nuclear localization signal (NLS)is brund by a compna sd moint Importins a and B and CAS are degraded in the nucieus The nuclear localization sequence usually contains around 20 ameno aoids The nuclear localization sequence contains severai consecutive basic (Arg or Lysi me The nuclear localization sequence is ocated almost anywhere in protein amino aad sequerce The nuclear localization sequence is emoved after targeting to the nucleusIn an XXYY human: two X chromosomes are inactivated in every cell one X chromosome is inactivated in each somatic cell none of the X chromosomes are inactivated in each somatic cell two X chromosomes are inactivated in each somatic cell
- The mutation of which of the following proto-oncogenes can lead to an increased susceptability to cancer, due to faulty growth factors? Multiple Choice BRCA1 p53 Ras Bax 4// Which of the following can become oncogenes by over-expression of the normal protein? src O Cip Op53 ✔Myc Jun U// Which CDK and cyclin does p53 ultimately target in DNA damaged conditions? O CDK1/cyclin E O CDK2/cyclin E CDK1/cyclin B CDK2/cyclin B
- Nucleation of straight, single line microfilaments is mediated by which of the following? Rho GTPase and Formin Rho GTPase and Arp 2/3 Cdc42 GTPase and Arp2/3 OCdc42 GTPase and Formin 14 < PreviousChromosome initiated has following sequence ab*cdefg *= centromere draw the chromosome that would result from the following mutations a paracentric inversion that includes defg b peri centric inversion of bcdeWhich histone is present in a chromatosome? O H1 H2A НЗ O All of the above