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- when an nitriles are treated with 1)NaOH,H2O/2)H3O+ , Explains what happens ?Describe the given synthetic pathway. Discuss type of reactions involved, the purpose of each reagent, and the relevance of each step. Provide brief explanation. Create a retrosynthetic map for the synthetic pathway in Question 1.Tamoxifen is a drug used to prevent and treat breast cancer. What are all the possible metabolic reactions for this drug? Aromatic hydroxylation Epoxidation ON-dealkylation Benzylic hydroxylation O Epoxidation followed by epoxide hydrolysis
- Which of the following would successfully perform the shown reaction? (A) (B) (C) (D) OH 1) NaH 2) EtBr NEt3 Mgº ether MeO OMe [TSOH] H ? PCC17. Which of the following will reduce the ester shown in the box? OCH3 A) NaH B) H2SO4 C) H2CrO4 D) LIAIH415) Draw the organic product in the following reaction: 1) LDA 2) CH,CH,I
- DRAW a possible synthesis for the reaction shown in the image. MeO MeO H₂N. OH4) Provide a mechanism that explains the formation of B and C when compound A is treated with NAOME. (Note: Compound C is not formed directly from A). 1) NaOMe, MeOH 2) H,O* A 2.Hydroxylamine, H2NOH, has both an OH functional group and an NH2 functional group, so it can feasibly undergo reaction with a ketone or an aldehyde to produce either an acetal or an imine-like compound called an oxime. (a) Draw each of these mechanisms for the reaction of hydroxylamine with acetone. (b) Which is the major product? Hint: Which step decides the outcome?