When considering an intramolecular Aldol addition that could make a 6-membered ring, what is the main deciding factor for Nu and E+? 1. electrophilicity of the carbonyl determines E+ (aldehyde if possible) because CH pKas are similar 2. CH pKas determines the Nu (aldehyde) because electrophilicity is similar 3. mixtures will always happen, there is no selectivity 4. both CH pKa and electrophilicity are equally important
When considering an intramolecular Aldol addition that could make a 6-membered ring, what is the main deciding factor for Nu and E+? 1. electrophilicity of the carbonyl determines E+ (aldehyde if possible) because CH pKas are similar 2. CH pKas determines the Nu (aldehyde) because electrophilicity is similar 3. mixtures will always happen, there is no selectivity 4. both CH pKa and electrophilicity are equally important
Organic Chemistry: A Guided Inquiry
2nd Edition
ISBN:9780618974122
Author:Andrei Straumanis
Publisher:Andrei Straumanis
Chapter16: Synthesis Workshop 1
Section: Chapter Questions
Problem 33CTQ
Related questions
Question
When considering an intramolecular Aldol addition that could make a 6-membered ring, what is the main deciding factor for Nu and E+?
1. electrophilicity of the carbonyl determines E+ (aldehyde if possible) because CH pKas are similar
2. CH pKas determines the Nu (aldehyde) because electrophilicity is similar
3. mixtures will always happen, there is no selectivity
4. both CH pKa and electrophilicity are equally important
Expert Solution
This question has been solved!
Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.
Step by step
Solved in 1 steps
Recommended textbooks for you
Organic Chemistry: A Guided Inquiry
Chemistry
ISBN:
9780618974122
Author:
Andrei Straumanis
Publisher:
Cengage Learning
Organic Chemistry: A Guided Inquiry
Chemistry
ISBN:
9780618974122
Author:
Andrei Straumanis
Publisher:
Cengage Learning