What proportion (in %) of the CFTR gene/DNA sequence is represented in the CFTR mRNA? The mRNA contains a 5’ UTR, ORF, and 3’ UTR. What proportion (in %) of the mRNA is represented in the ORF? 3:40 PM4)11/9/2020huluAutoSave O offCystic Fibrosis Information Flow Worksheet_BIOL220_F19(1) - WordP SearchWilliams, Aniyah Elise WAFileDesignReferencesMailingsReviewViewHelpA ShareP CommentsHomeInsertLayoutThe figures below depict the steps in the expression of CFTR. Using the information in thefigure, answer the questions below.CFTR gene e(-190,00base pairs)ExonsIntronsTranscriptionCFTR MRNA(6132 nucleotides)5' UTR(132 nucleotides)Translated region - ORF(4443 nucleotides)3' ÚTR(1557 nucleotides)TranslationPrimary structure of the CFTRprotein showing the locationof the major domains.1480 amino acids total length.NH,--COOHTMD1NBD1RTMD2NBD2Folding into tertiary structure andembedding in cell membraneTMD1 and TMD2 aretransmembrane domains,each consisting of 6 segments(1-6 and 7-12, respectively).ICLS (intracellular loops) andECLS (extracellular loops)connect segments oftransmembrane domains andcontribute to proper functionof the CFTR channel.TMD1TMD2ECL1ECL4ECL2 ECL3ECL5 ECL6Lumen1 23 45 6 7 89 10 11 12Inside cellNBD1 and NBD2 are nucleotidebinding domains, localized on thecytoplasmic side of the cell membrane.ATP hydrolysis of the NBD domains isrequired for the CFTR to changeconformation and function as an ion channel.R represents the regulatorydomain. Phosphorylationof the R-domain is requiredfor the CFTR to changeconformation and functionas an ion channel.N.ICL1ICL2ICL3ICL4RNBD2NBD1Page 1 of 61018 wordsD Focus目+100%

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Description: What proportion (in %) of the CFTR gene/DNA sequence is represented in the CFTR mRNA? The mRNA contains a 5’ UTR, ORF, and 3’ UTR. What proportion (in %) of the mRNA is represented in the ORF? 3:40 PM4)11/9/2020huluAutoSave O offCystic Fibrosis Infor

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What proportion (in %) of the CFTR gene/DNA sequence is represented in the CFTR mRNA? The mRNA contains a 5’ UTR, ORF, and 3’ UTR. What proportion (in %) of the mRNA is represented in the ORF?

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