What is the likely function of the cytosolic cAMP in this transduction pathway?   Question 16 options:   a)  It is a competitive inhibitor of the protein kinase.   b)  It is a hormone.   c)  It is a messenger RNA.   d)  It is a coenzyme.   e)  It is a second messenger

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Chapter39: Information Flow And The Neuron
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What is the likely function of the cytosolic cAMP in this transduction pathway?

 

Question 16 options:

 

a) 

It is a competitive inhibitor of the protein kinase.

 

b) 

It is a hormone.

 

c) 

It is a messenger RNA.

 

d) 

It is a coenzyme.

 

e) 

It is a second messenger.

H
H₁ H
ATP synthase
UCP1
Beta-3 adrenergic receptor-
H₁
H₁
H
Cytosol
H' H
H
H
H
H
H
H
H
Mitochondria
inner-membrane
-Norepinephrine
G-protein
Fatty acids
Mitochondria
outer-membrane
CAMP
Protein
kinase A
Lipase
ATP
1. Norepinephrine binds the Beta-3 adrenergic receptor.
2. The Beta-3 adrenergic receptor activates a G-protein.
3. The activated G-protein activates an adenylyl cyclase.
4. The activated adenylyl cyclase converts ATP into CAMP.
5. CAMP activates the protein kinase A.
Adenylyl cyclase
Triacylglycerol
In brief, the transduction pathway that regulates the activation/inhibition of UCP1
under the control of norepinephrine is as follows:
6. The protein kinase A activates a lipase through phosphorylation.
7. The activated lipase hydrolyzes triacylglycerol (the main constituent of body
fat) into fatty acids.
8. Fatty acids activate UCP1.
Transcribed Image Text:H H₁ H ATP synthase UCP1 Beta-3 adrenergic receptor- H₁ H₁ H Cytosol H' H H H H H H H H Mitochondria inner-membrane -Norepinephrine G-protein Fatty acids Mitochondria outer-membrane CAMP Protein kinase A Lipase ATP 1. Norepinephrine binds the Beta-3 adrenergic receptor. 2. The Beta-3 adrenergic receptor activates a G-protein. 3. The activated G-protein activates an adenylyl cyclase. 4. The activated adenylyl cyclase converts ATP into CAMP. 5. CAMP activates the protein kinase A. Adenylyl cyclase Triacylglycerol In brief, the transduction pathway that regulates the activation/inhibition of UCP1 under the control of norepinephrine is as follows: 6. The protein kinase A activates a lipase through phosphorylation. 7. The activated lipase hydrolyzes triacylglycerol (the main constituent of body fat) into fatty acids. 8. Fatty acids activate UCP1.
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