What benefits would you expect from adding SERT/NET inhibition to an opioid? 1. less development of mu-opioid tolerance 2. reduction of inflammatory responses 3. increased effectiveness of the descending pain inhibitory pathways.

Essentials of Pharmacology for Health Professions
7th Edition
ISBN:9781305441620
Author:WOODROW
Publisher:WOODROW
Chapter19: Analgesics, Sedatives, And Hypnotics
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What benefits would you expect from adding SERT/NET inhibition to an opioid?

1. less development of mu-opioid tolerance

2. reduction of inflammatory responses

3. increased effectiveness of the descending pain inhibitory pathways.

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