w that although he has clinical findings of CF, his eat chloride concentration is normal. The sweat chlo- e concentration is normal in less than 2% of patients h CF. His pediatrician and parents want to know if A analysis can determine whether he indeed has CF. Would DNA analysis be useful in this case? Briefly outline the steps involved in obtaining a DNA diag- nosis for CF. If he has CF, what is the probability that he is homo- zygous for the AF508 mutation? (Assume that 85% of CF mutations could be detected at the time you are consulted and that his parents are from northern Europe, where the AF508 allele has a frequency of 0.70.) If he does not have the AF508 mutation, does this disprove the diagnosis? Explain.
w that although he has clinical findings of CF, his eat chloride concentration is normal. The sweat chlo- e concentration is normal in less than 2% of patients h CF. His pediatrician and parents want to know if A analysis can determine whether he indeed has CF. Would DNA analysis be useful in this case? Briefly outline the steps involved in obtaining a DNA diag- nosis for CF. If he has CF, what is the probability that he is homo- zygous for the AF508 mutation? (Assume that 85% of CF mutations could be detected at the time you are consulted and that his parents are from northern Europe, where the AF508 allele has a frequency of 0.70.) If he does not have the AF508 mutation, does this disprove the diagnosis? Explain.
Medical Terminology for Health Professions, Spiral bound Version (MindTap Course List)
8th Edition
ISBN:9781305634350
Author:Ann Ehrlich, Carol L. Schroeder, Laura Ehrlich, Katrina A. Schroeder
Publisher:Ann Ehrlich, Carol L. Schroeder, Laura Ehrlich, Katrina A. Schroeder
ChapterCom: Comprehensive Medical Terminology Review
Section: Chapter Questions
Problem 29RS
Related questions
Question
Transcribed Image Text:Johnny, 2 years of age, is failing to thrive. Investigations
show that although he has clinical findings of CF, his
sweat chloride concentration is normal. The sweat chlo-
ride concentration is normal in less than 2% of patients
with CF. His pediatrician and parents want to know if
DNA analysis can determine whether he indeed has CF.
a. Would DNA analysis be useful in this case? Briefly
outline the steps involved in obtaining a DNA diag-
nosis for CF.
b. If he has CF, what is the probability that he is homo-
zygous for the AF508 mutation? (Assume that 85%
of CF mutations could be detected at the time you
are consulted and that his parents are from northern
Europe, where the AF508 allele has a frequency of
0.70.)
c. If he does not have the AF508 mutation, does this
disprove the diagnosis? Explain.
Expert Solution
This question has been solved!
Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.
Step by step
Solved in 5 steps
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Recommended textbooks for you
Medical Terminology for Health Professions, Spira…
Health & Nutrition
ISBN:
9781305634350
Author:
Ann Ehrlich, Carol L. Schroeder, Laura Ehrlich, Katrina A. Schroeder
Publisher:
Cengage Learning
Comprehensive Medical Assisting: Administrative a…
Nursing
ISBN:
9781305964792
Author:
Wilburta Q. Lindh, Carol D. Tamparo, Barbara M. Dahl, Julie Morris, Cindy Correa
Publisher:
Cengage Learning
Medical Terminology for Health Professions, Spira…
Health & Nutrition
ISBN:
9781305634350
Author:
Ann Ehrlich, Carol L. Schroeder, Laura Ehrlich, Katrina A. Schroeder
Publisher:
Cengage Learning
Comprehensive Medical Assisting: Administrative a…
Nursing
ISBN:
9781305964792
Author:
Wilburta Q. Lindh, Carol D. Tamparo, Barbara M. Dahl, Julie Morris, Cindy Correa
Publisher:
Cengage Learning
Principles Of Radiographic Imaging: An Art And A …
Health & Nutrition
ISBN:
9781337711067
Author:
Richard R. Carlton, Arlene M. Adler, Vesna Balac
Publisher:
Cengage Learning