This figure' shows that the decay "chain" starts with an a decay of 2Ac to produce "Fr, which itself undergoes a decay to "X1", and so on, until the final production of the stable "Bi isotope via a beta- decay process from "XS". Note that isotope "X2" has two different decay channels, both of which result in "XS": 98% of "X2" undergoes B decay to "X3" (which subsequently decays by emitting a to produce XS"), while 2% of X2" decays to "X4" via a decay (which subsequently undergoes B* decay to "X5"). 1. Given the type of decay process, provide the element and nucleon number (e.g. 2"Fr) for each of the isotopes X1, X2, X3, X4 and XS. 2. Assume a chemist in Dr. Ramogida's lab requires 8 hours from the time of receipt of 2Ac to incorporate it into a chemically synthesized carrier compound that can be used for cancer treatment. If they are given 0.450 mg of 2Ac, what is the mass of *Ac remaining at the end of the 8 hours, given its half-life of 9.9 days? 3. If their compound is shipped around the world for treatment of cancer patients, a key consideration is how long it remains active. Starting with the amount that leaves Dr. Ramogida's lab, for how long does at least 10% of the *Ac remain, which could be used for treatment? 4. The half-life of 21Fr is considerably shorter than "Ac: 4.8 minutes. Would you recommend to Dr. Ramogida's team to try to synthesize molecules that can target Francium to tumours, rather than using Actinium? Explain your reasoning. Figure adapted from "Development of Ac Radiopharmaceuticals: TRIUMF Perspectives and Experiences", by Robertson, Ramogida, Schaffer and Radchenko. Current Radiopharmaceuticals 11, 156 (2018)
This figure' shows that the decay "chain" starts with an a decay of 2Ac to produce "Fr, which itself undergoes a decay to "X1", and so on, until the final production of the stable "Bi isotope via a beta- decay process from "XS". Note that isotope "X2" has two different decay channels, both of which result in "XS": 98% of "X2" undergoes B decay to "X3" (which subsequently decays by emitting a to produce XS"), while 2% of X2" decays to "X4" via a decay (which subsequently undergoes B* decay to "X5"). 1. Given the type of decay process, provide the element and nucleon number (e.g. 2"Fr) for each of the isotopes X1, X2, X3, X4 and XS. 2. Assume a chemist in Dr. Ramogida's lab requires 8 hours from the time of receipt of 2Ac to incorporate it into a chemically synthesized carrier compound that can be used for cancer treatment. If they are given 0.450 mg of 2Ac, what is the mass of *Ac remaining at the end of the 8 hours, given its half-life of 9.9 days? 3. If their compound is shipped around the world for treatment of cancer patients, a key consideration is how long it remains active. Starting with the amount that leaves Dr. Ramogida's lab, for how long does at least 10% of the *Ac remain, which could be used for treatment? 4. The half-life of 21Fr is considerably shorter than "Ac: 4.8 minutes. Would you recommend to Dr. Ramogida's team to try to synthesize molecules that can target Francium to tumours, rather than using Actinium? Explain your reasoning. Figure adapted from "Development of Ac Radiopharmaceuticals: TRIUMF Perspectives and Experiences", by Robertson, Ramogida, Schaffer and Radchenko. Current Radiopharmaceuticals 11, 156 (2018)
Chemistry: An Atoms First Approach
2nd Edition
ISBN:9781305079243
Author:Steven S. Zumdahl, Susan A. Zumdahl
Publisher:Steven S. Zumdahl, Susan A. Zumdahl
Chapter18: The Nucleus: A Chemist's View
Section: Chapter Questions
Problem 28E
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