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Methadone elimination has very large patient to patient variability. A slow
1. 2.5 days
2. 6.5 days
3 4.5 days
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- Drug A has an half-live of 6 hours, a volume of distribution of 40 liters, and a bioavailability fraction of 0.4. The administration of a 200 mg oral tablet to a 62 year old patient give an AUC = 17.9 mg/L/hr. Calculate the total body clearance ? Please answer it. I will really upvoteYou are requested to recommend a dosage regimen for a patient (5S years old, 80 kg) to achieve plasma levels of 25 mg/L of an antiepileptic agent with an elimination half-life of 11 hrs and an apparent Vd of 0.02 L/kg. The tablets are 75% bioavailable and are available as 10 mg and 40 mg tablets. The ideal dosage regimen for this patient is: 10 mg twice daily 10 mg four times a day 40 mg daily 40 mg twice dailyA client has been ordered Minipress (prazosin hydrochloride) 2 mg po twice a day (first 2 mg dose to be taken in the morning and the second 2 mg dose to be taken at bedtime). The medication is available as Minipress (prazosin hydrochloride) 1 mg capsules. 1. what is the main conversions factor that you will be using to solve this equation? 2. How many capsules should be administered to this client for the whole day?
- A%252F%252Fbbniagaraccc.sln.suny.edu%252Fwe ignment Saved The drip rate of a dobutamine IV depends on the dose (in mcg/min), the weight of the patient, and the dobutamine solution concentration (in mg/ml). For a concentration of 2 mg/ml, the drip rate (in ml/hour), is described by the following formula: Drip rate = 0.03 [patient body mass (kg) × dose infusion rate (mcg/kg-min)] For a patient weighing 209 pounds and a dose infusion rate of 20 mcg/min for every kilogram of body mass, what is the IV drip rate? ml/hrAccording to the diagram attached the therapeutic range of the drug is considered low, this means that the drug is: 120 MTC 100 80 60 40 МЕС 20 10 12 time in hours Select one: Not very safe It is very safe It is very potent It is not very potent concentrationA patient with a rash gets a combination prescription from his physician to help alleviate the itching and moisturize the skin. The prescription is for 60% ingredient A and 40% of ingredient B for a total of 155 g (in a single tube). The patient has 3 refills on this prescription and wants to pick up the entire amount today: how much in g is that? Hint: 3 refills includes an original prescription so the total amount to be picked up is 4 tubes)
- 100 mg dose of Drug X is administered via IV at 7 hours, blood drug concentration is 5 mcg/mL Half-life of the Drug X is 5 hours A. Find the blood concentration after 6 hours if the dose is 1g (should be between 50.39 and 61.6) B. Minimum effective concentration is 2 mcg/mL. IF the first dose was 100mg of Drug X, how many hours after the dose would reach to 2mcg/mL. (When should the 2nd dose be given). (should be between 12.06 and 14.74)Answer the questions based on the data table. [s] mM 0.333 0.40 0.50 0.666 1.0 2.0 V (M/s) Uninhibited 1.65 x 107 1.86 x 107 2.13 x 107 2.49 x 107 2.99 x 107 3.72 x 107 V (M/s) x 107 Inhibitor A 1.05 x 107 1.21 x 107 1.43 x 107 1.74 x 107 2.22 x 107 3.08 x 107 Determine the Km and Vmax of the enzyme. Determine the type of inhibition imposed by inhibitor A. Determine the type of inhibition imposed by inhibitor B. V (M/s) x 107 Inhibitor B 0.794 x 107 0.893 x 107 1.02 x 107 1.19 x 107 1.43 x 107 1.79 x 107Nervousness, heart palpitations and tachycardia are symptoms of toxicity of which of the following drugs? Question 23 Not yet answered Marked out of O Methimazole 1.00 O Levothyroxine P Flag question PTU Propranolol
- A patient needs to receive 50 mL of Claforan (cefotaxime) IV over 30 minutes with a drop factor of 60 gtt/mL. Calculate how many drops per minute are required so that all 50 mL is infused over 30 minutes.Your patient is admitted with cellulitis and is ordered cephalexin 0.5g PO every six hours. The safe dosage parameter is 25mg/kg/day PO in 2 to 4 divided doses (Max: 2 g/day). Your patient weighs 176 pounds. The medication is available in 250mg tablets Is the patient’s daily dose within the safe dose parameters? Show your calculationsThe plasma of half-life of aspirin is t1/2 = 20 minutes; ibuprofen t1/2 = 2 hours. Both agents are dosed q 4 to 6 hours. Compared to ibuprofen, APAP's dosing can be much longer than it's plasma half-life because it is: 1. more toxic, so cannot be taken as often 2. more selective for COX1 than is ibuprofen 3. an irreversible inhibitor