they do have significant pharmacological differences.

Comprehensive Medical Terminology
4th Edition
ISBN:9781133478850
Author:Jones
Publisher:Jones
Chapter22: Pharmacology
Section: Chapter Questions
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Two of the most commonly used NSAIDS are ibuprofen and naproxen. Although they are both classified as "non-selective," they do have significant pharmacological differences. 

NSAID             COX-2                 COX-1

Ibuprofen         15                         1

Naproxen          1.3                        2.2

1. irreversible inhibition of Cox-1

2. increased bleeding

3. reduced joint inflammation

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