The number of ATP molecules that can be made from the oxidation of cis-11-heptadecenoic acid (C-17) to CO2 and water (NADH = 3 ATP and FADH2 = 2 ATP) is: Select an answer and submit. For keyboard navigation, use the up/down arrow keys to select an answer. a 125 b 115 c 112 d 122 e 109 f 131 g 129 h 117 i 110
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- nvestigate references dealing with the technical and ethical challenges surrounding mitochondrial replacement therapy (MRT). Consider the following questions: Differentiate between MRT methods: pronuclear transfer (PNT) versus maternal spindle transfer (MST). Much of the controversy surrounding MRT methods has been triggered by the phrase “three-parent babies” in media headlines. Do you think that this phrase is an accurate description of children born following mitochondrial replacement? Summarize the ethical arguments used to support and oppose the use of MRT in humans. In your opinion, which arguments have validity, and whyplease help me I can't find answers for these questions: here is the link for the article https://www.pbs.org/wgbh/nova/transcripts/2805cancer.html What type of substances are angiostatin and endostatin and where are they produced? What do they do? A) describe the experiments using cow bones to discover anti-angiogenic substances. Why was this used as a source of these potential proteins? B) describe the “accidental” discovery of a novel antiangiogenic substance because of lab contamination?Glucose-6-phosphatase deficiency (G6PD), also known as von Gierke disease, is glycogen storage disease. It is an autosomal recessive disease occurring most frequently in males of African or Middle Eastern descent. G6PD is involved in many reactions, but we will focus on the following simplified pathway: The conversion of glycogen to glucose is called:
- Leber’s Hereditary Optic Neuropathy (LHON) is a disease that involves degeneration of neural cells in the retina and results in loss of central vision. The disease is caused by mutations in any one of three genes in the mitochondrial genome that encode proteins involved in oxidative phosphorylation. In a genetic counseling clinic, a woman and her husband seek advice on the potential that any of their children would be afflicted with LHON. The husband's mother and father, both exhibit symptoms of the disease, but the woman does not. What is a reasonable advising statement to make? a. The couple should be advised that all of their children are likely to display symptoms of LHON. b. There is not enough information to advise this couple. c. The couple should be advised that none of their children will be affected. d. The couple should be advised that all their male children will display symptoms of LHON, but female children will be unaffected. e. The couple should be…Leber’s Hereditary Optic Neuropathy (LHON) is a disease that involves degeneration of neural cells in the retina and results in loss of central vision. The disease is caused by mutations in any one of three genes in the mitochondrial genome that encode proteins involved in oxidative phosphorylation. In a genetic counseling clinic, a woman and her husband seek advice on the potential that any of their children would be afflicted with LHON. The husband's mother and father, both exhibit symptoms of the disease, but the woman does not. What is a reasonable advising statement to make?BIM-46187 is a protein inhibitor that binds to the a-subunit of the G, protein. It prevents the GDP/GTP exchange and prevents activity of the G protein. Which of the following would you expect to see lower levels of as a result? You can select more than one answer. S-S Mol. W: 795.11 Image: https://aobious.com/aobious/protein-inhibitors/1086-bim-46187.html Select one or more: O a. Cyclic AMP (CAMP) O b. Tyrosine kinase HSP O d. Adenylyl Cyclase (AC) O e. DAG O f. JAK O g. IP3
- Hemoglobin glycation (so named to distinguish it from glycosylation, which is the enzymatic transfer of glucose to a protein) is a non-enzymatic process that involves reaction of the N-terminal amino group of hemoglobin and glucose. The amount of glycated hemoglobin (GHB) is usually about 5% of total hemoglobin (and corresponds to a blood glucose concentration of 120 mg/100 mL). However, in people with untreated diabetes this value may be as high as 13%, which indicates an average blood level of about 300 mg/100 mL -dangerously high. One of the aims of insulin therapy is to maintain GHB values of about 7%. Draw a possible chemical scheme for the glycation of hemoglobin.Leigh syndrome is characterized by psychomotor regression: that is, the progressive loss of mental andmovement abilities. Patients also suffer from lacticacidosis, a condition in which mitochondrial respiration is deficient, so their tissues metabolize glucoseanaerobically, leading to the buildup of lactate. Somepatients with Leigh syndrome have a mutation in themitochondrial gene MT-CO3, which encodes a subunit of the electron transport complex cytochromec oxidase. Other patients diagnosed with Leigh syndrome have a loss-of-function mutation in the nucleargene SURF1, which encodes a factor needed for theassembly of this same enzyme complex.a. How can the same symptoms result from mutationsin a mitochondrial gene and from mutations in anuclear gene?The major enzyme that metabolizes caffeine is: о CYP1A2 0 CYP2B6 o CYP3A4 0 CYP2A6 о CYP2C9
- An individual with an argininosuccinase deficiency is administered benzoate and arginine. This individual will have their nitrogen removed from the body as which of the following compounds? SELECT ALL ANSWERS THAT APPLY. ** This is NOT a multiple choice question! ** O. hippurate O II. phenylacetylglutamine O I. citrulline OV. carbamoyl phosphate Ov. argininosuccinate O VI. arginine OVI. fumarate O VII. benzoylglycineWhich one of the following statements concerning disorders of muscle metabolism presented in class is incorrect? a) Mutations in animals can spread rapidly because of line breeding to prolific males. b) The low rate of metabolism and ATP consumption in muscle and nerve makes effects of mitochondrial myopathies less observable in these tissues. c) Glycogen storage diseases resulting from mutations in glycolytic and glycogen pathway genes typically cause accumulation of abnormal glycogen and/or exercise intolerance. d) Lipid storage myopathies can result from deficiencies in enzymes of Beta-oxidation and lead to the accumulation of triglyceride droplets in muscle fibers. .Cyclic AMP (CAMP) is an important signaling molecule in cells. The synthesis and degradation of CAMP is diagrammed in the following figure: ATP ©2017 Pearson Education, Inc. 12pt Adenylyl cyclase Edit View Insert Format Tools Table Paragraph Pyrophosphate 3'c- P-P₁ 5'C BI Both caffeine (coffee, cola) and theophylline inhibit the enzyme phosphodiesterase that converts CAMP to AMP, allowing cAMP levels to temporarily remain high. Briefly discuss the possible effect of these drugs on the second messenger action of CAMP. What might the effect of caffeine of theophylline be on a signaling pathway? CAMP UA Phosphodiesterase T² H₂O AMP ⠀