The following molecule was once considered as a drug candidate by a large pharmaceutical company HO a. For the functional group indicated, write the pKa expression for the group acting as an acid and identify an appropriate pKa value using the table provided. b. For the functional group indicated, write the pKa expression for the group acting as a base and identify an appropriate pKa value using the table provided. c. Use your pKa data to predict whether the group will act as an acid, base or both when used as a drug. d. Use your pKa data, and answer in part c, to predict whether the molecule is likely to be soluble at pH 7.4.
The following molecule was once considered as a drug candidate by a large pharmaceutical company HO a. For the functional group indicated, write the pKa expression for the group acting as an acid and identify an appropriate pKa value using the table provided. b. For the functional group indicated, write the pKa expression for the group acting as a base and identify an appropriate pKa value using the table provided. c. Use your pKa data to predict whether the group will act as an acid, base or both when used as a drug. d. Use your pKa data, and answer in part c, to predict whether the molecule is likely to be soluble at pH 7.4.
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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