The following is a Hill Plot for a receptor-ligand interaction:006(0-1) 60log420-2-4-6-60246810log [L] (nM)TWhat fold-difference exists between the KD of the first and the KD of the second binding event?1,000,000610,000,000,000210

Given:Hill plot for receptor-ligand interaction.Determine the fold difference.

The following is a Hill Plot for a receptor-ligand interaction: 8 6 (0-1) 601 4 2 0 -2 -4 -6 -6 4 -2 0 2 4 8 10 log [L] (nM) What fold-difference exists between the KD of the first and the KD of the second binding event?

The following is a Hill Plot for a receptor-ligand interaction: 8 6 (0-1) 601 4 2 0 -2 -4 -6 -6 4 -2 0 2 4 8 10 log [L] (nM) What fold-difference exists between the KD of the first and the KD of the second binding event?

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

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Question

The following is a Hill Plot for a receptor-ligand interaction:
00
6
(0-1) 60
log
4
2
0
-2
-4
-6
-6
0
2
4
6
8
10
log [L] (nM)
T
What fold-difference exists between the KD of the first and the KD of the second binding event?
1,000,000
6
10,000,000,000
2
10

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Step 1: Introduction

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Step 2: Consider the interaction between protein(P) and ligand (L) is:

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Step 3: Hill equation

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Step 4: Showng plot

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Step 5: Calculating fold difference

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