The conversion of acetyl CoA to malonyl CoA is the rate-limiting step in fatty acid synthesis. Which of the following enzyme catalyzes the above-mentioned reaction? O Acetyl CoA decarboxylase O Acetyl CoA carboxylase O Malonyl CoA synthase O Malonyl CoA synthetase
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- Which of the following is NOT part of the multi-enzyme complex of fatty acid synthase? O enoyl-ACP reductase O acetyl CoA carboxylase O 3-hydroxybutyrylACP-dehydratese O B-ketoacyl-ACP reductaseWhat enzyme(s) is/are specifically required for the oxidation of a Aeven monounsaturated fatty acid? (select all that apply) O Methylmalonyl CoA Mutase O enoyl-CoA Hydratase 43-enoyl-CoA isomerase Thiolase 2,4-Dienoyl-CoA Reductase OPropionyl-CoA carboxylaseWhat is the final reaction in the final round of fatty acid synthase? Acetyl-CoA ACP Transacylase Beta-Ketoacyl- ACP Synthase Beta-Ketoacyl- ACP Dehydrase Palmitoyl thioesterase Malonyl-CoA ACP Transacylase Enoyl-ACP Reductase
- On these following choices, Malonyl CoA synthase, Malonyl CoA synthetase, Acetyl CoA carboxylase and Acetyl CoA decarboxylase, what is the correct answer in fatty acid synthesis?Fatty acids are activated for breakdown through the action of acyl-CoA synthestase. Which of the following statements regarding acyl-CoA synthetase is not true? ● It catalyzes the addition of CoA to the fatty acid One of the products of the reaction is ADP. O The free energy change for the reaction catalyzed by this reaction is close to 0 kJ/mol, but the subsequent hydrolysis of pyrophosphate drives the reaction forward. O The reaction results in the formation of a thioester bond.Identify a pathway for utilization of the four carbons of acetoacetate in cholesterol biosynthesis. Carry your pathway as far as the rate-determining reaction in cholesterol biosynthesis. Drag the appropriate labels to their respective targets. succinyl-CoA succinate acetyl-CoA CoA-SH acetoacetyl-CoA HMG-CoA 2NADP 2NADPH+ 2H acetoacetate K UHL return to a mevalonate + CoA-SH
- What is(are) the product(s) of the thiolase reaction involving a sixteen carbon ß-ketoacyl substrate and CoASH? O A 14 carbon acyl-CoA molecule and acetyl-CoA O An 18 carbon acyl-CoA molecule and acetyl-CoA O acetoacetyl coA O An 18 carbon acyl-CoA moleculeStep 2 of B-oxidation involves a reaction with chemistry characterized as a dehydration. B-Oxidation is shown below. H HO || || C-C-S – CoA FAD но R-CH2- C Acyl-CoA dehydrogenase H-C-C -S- CoA Acetyl-CoA Fatty acyl-CoA H FADH2 - CH2 - -c-S- CoA R- Thiolase Fatty acyl-CoA shortened by two carbons COA-SH H. он Successive cycles R-CH2-C-C- -C-S- CoA R– CH2 C=C-C-S-CoA H B-Ketoacyl-Co.A trans-A²Enoyl-CoA NADH + H* H,0 H H L-Hydroxyacyl-CoA dehydrogenase Enoyl-CoA hydratase R- CH,-c-c-C- S-CoA Но H NAD+ L-B-Hydroxyacyl-CoA True O FalseWhat is(are) the only active site(s) not used in the second round of fatty acid synthase? Select all that apply. Group of answer choices Acetyl-CoA ACP Transacylase Beta-Ketoacyl- ACP Synthase Beta-Ketoacyl- ACP Dehydrase Palmitoyl thioesterase Malonyl-CoA ACP Transacylase Enoyl-ACP Reductase
- All of the following are accurate contrasts for beta oxidation vs fatty acid synthesis except which of the following statements? Group of answer choices The hydroxylacyl group differs in stereochemistry between beta oxidation and biosynthesis CoA is the acyl carrier group in beta oxidation, acyl carrier protein is the carrier in biosynthesis The carbon unit resulting from beta oxidation is acetyl-CoA, the carbon unit for biosynthesis is malonyl-CoA FAD is an electron acceptor in beta oxidation, NADP+ is the electron acceptor in biosynthesisThe following reaction is a vitamin B12-dependent reaction that proceeds via a mechanism analogous to that of the methylmalonyl-CoA mutase reaction. H Н4 H 1 H3N 2 H `H H HO b H H5 Identify which atoms in the product(s) correspond to the numbered atoms in the reactant. Atom a corresponds to atom Atom b corresponds to atom Atom c corresponds to atomWhich of the following statements is TRUE about fatty acid biosynthesis? Citrate carries malonyl CoA to the cytosol. O Acetyl ACP is the donor of the acetyl group. O NADPH is used as the reducing equivalent in the process. O The product detaches from the fatty acid synthase complex when the chain length is usually 18 carbons.