The B-cell co-receptor, composed of CD19/CD21/CD81, is a receptor that binds to complement fragments such as C3dg. When an antigen bound by the BCR on a B cell has also been tagged with C3dg, the B-cell co-receptor is stimulated together with the BCR. Signaling through the co-receptor O inhibits BCR signaling by leading to PIP3 dephosphorylation. inhibits BCR signaling by leading to ITAM dephosphorylation. O enhances BCR signaling by recruiting and activating PI 3-kinase. enhances BCR signaling by bringing the Src kinase together with Ig-a and Ig-ß.
The B-cell co-receptor, composed of CD19/CD21/CD81, is a receptor that binds to complement fragments such as C3dg. When an antigen bound by the BCR on a B cell has also been tagged with C3dg, the B-cell co-receptor is stimulated together with the BCR. Signaling through the co-receptor O inhibits BCR signaling by leading to PIP3 dephosphorylation. inhibits BCR signaling by leading to ITAM dephosphorylation. O enhances BCR signaling by recruiting and activating PI 3-kinase. enhances BCR signaling by bringing the Src kinase together with Ig-a and Ig-ß.
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Transcribed Image Text:The B-cell co-receptor, composed of CD19/CD21/CD81, is a receptor that binds to complement fragments such as C3dg. When
an antigen bound by the BCR on a B cell has also been tagged with C3dg, the B-cell co-receptor is stimulated together with the
BCR. Signaling through the co-receptor
inhibits BCR signaling by leading to PIP3 dephosphorylation.
inhibits BCR signaling by leading to ITAM dephosphorylation.
enhances BCR signaling by recruiting and activating PI 3-kinase.
enhances BCR signaling by bringing the Src kinase together with Ig-a and Ig-ß.
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