Substrate K_(µM) k_(min) cat Ethanol 960 480 1-Butanol 440 450 1-Нехanol 69 182 12-Hydroxydodecanoate 50 146 All-trans-retinol 20 78 Benzyl alcohol 410 82 2-Butanol 250,000 285 Cyclohexanol 31,000 122
Catalysis and Enzymatic Reactions
Catalysis is the kind of chemical reaction in which the rate (speed) of a reaction is enhanced by the catalyst which is not consumed during the process of reaction and afterward it is removed when the catalyst is not used to make up the impurity in the product. The enzymatic reaction is the reaction that is catalyzed via enzymes.
Lock And Key Model
The lock-and-key model is used to describe the catalytic enzyme activity, based on the interaction between enzyme and substrate. This model considers the lock as an enzyme and the key as a substrate to explain this model. The concept of how a unique distinct key only can have the access to open a particular lock resembles how the specific substrate can only fit into the particular active site of the enzyme. This is significant in understanding the intermolecular interaction between proteins and plays a vital role in drug interaction.
Alcohol dehydrogenase (ADH) is inhibited by numerous
alcohols. Using the data given in the following table, calculate the kcat/Km values for each of the alcohols. Which of the
listed alcohols is most easily
dehydrogenase?
Kinetic parameters for hamster testes ADH.
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