Starting with 3,5-hexadiyn-1-ol, select reagents from the table below that should be used to synthesize 1,8-octanediol. 3,5-hexadiyn-1-ol 1,8-octanediol (The reaction may require more than one step; if so, write the letters in the order that they are used, e.g., abc. If two or more in conversion to the same product are possible, show only one of them. Omit steps that are part of the workup procedure.) Reagents available a. NINH, / NH, 1. TBDMS-CI b. H₂/Pt 9. Bu,N*F c. H₂/ Lindlar catalyst h. Na, NH (lig) d. PCC Lethylene oxide e. H₂O Reagent(s):
Reactions of Ethers
Ethers (R-O-R’) are compounds formed by replacing hydrogen atoms of an alcohol (R-OH compound) or a phenol (C6H5OH) by an aryl/ acyl group (functional group after removing single hydrogen from an aromatic ring). In this section, reaction, preparation and behavior of ethers are discussed in the context of organic chemistry.
Epoxides
Epoxides are a special class of cyclic ethers which are an important functional group in organic chemistry and generate reactive centers due to their unusual high reactivity. Due to their high reactivity, epoxides are considered to be toxic and mutagenic.
Williamson Ether Synthesis
An organic reaction in which an organohalide and a deprotonated alcohol forms ether is known as Williamson ether synthesis. Alexander Williamson developed the Williamson ether synthesis in 1850. The formation of ether in this synthesis is an SN2 reaction.
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