Simvastatin (trade name: ZocorTM) is a pharmaceutical used to treat elevated blood lipids (i e. high cholesterol). It contains 7 chirality centers (which allows for 128 different stereoisomers!) Determine the configuration of each chirality center. HO O CH3, ... O H OI ) H O XII H CH3

Simvastatin (trade name: ZocorTM) is a pharmaceutical used to treat elevated blood lipids (i e. high cholesterol). It contains 7 chirality centers (which allows for 128 different stereoisomers!) Determine the configuration of each chirality center. HO O CH3, ... O H OI ) H O XII H CH3

Organic Chemistry: A Guided Inquiry

2nd Edition

ISBN:9780618974122

Author:Andrei Straumanis

Publisher:Andrei Straumanis

Chapter12: Chirality

Section: Chapter Questions

Problem 19E

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Question

Simvastatin (trade name: Zocor™M) is a pharmaceutical used to treat elevated blood lipids (i.e. high
cholesterol). It contains 7 chirality centers (which allows for 128 different stereoisomers!) Determine the
configuration of each chirality center.
HOL.
O
CH3
H
O
H
Ou
yot
H
O
XII
H
по
/ CH3

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Step 1: Configuration of chiral centers

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Step 2: The configuration of chiral carbons in the given molecule

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Step 3: The configuration of chiral carbons in the given molecule

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Step 4: The configuration of chiral carbons in the given molecule

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