Answered: Show a reasonable mechanism for the…

Show a reasonable mechanism for the following reaction (Hint: Michael addition followed by intramolecular aldol condensation) r NaOEt, EtOH A As

Organic Chemistry

9th Edition

ISBN:9781305080485

Author:John E. McMurry

Publisher:John E. McMurry

Chapter23: Carbonyl Condensation Reactions

Section23.SE: Something Extra

Problem 41MP

See similar textbooks

Related questions

Q: Consider the reaction shown below. For a particular concentration of sodium methoxide, the…

A: Elimination reactions are of two types, first order and second order. First order elimination…

Q: Ecell= 0.225 volts E-0.150 volts cell T= 474 Kelvin n=1 R= 8.314 J/mol K F= 96500 C/mole electrons…

Q: (4) Assume that the change in concentration of N2O4 is small enough to be neglected in the following…

A: If the value of kc is very small, it indicates that only a small amount of the reactant is converted…

Q: 3 A technician measured 50.0 mL of a strong acid stock solution and diluted it to 0.300 mol/L…

Q: 5. For each of the reactions shown below, provide if the mechanism goes through an SN', S2, E1, or…

Q: la) он. Br Br Дон сиз Сион

A: Here we have to write the mechanism for the conversion of the following starting material to target…

Q: 1. Calculate the percentage of ionic characters for Cesium Chloride (CsCl). 2. Based on the answer…

Q: Identify the reagents necessary for the following transformation: - NH₂ The transformation above can…

A: Ammonia can act as a nucleophile and substitute Cl from Acyl chloride and LiAlH4 reduces amides to…

Q: Reaction 1: H2(g)+Cl2(g)⟶2HCl(g)ΔH=−184.6 kJ Reaction 2: 2OF2(g)⟶O2(g)+2 F2(g)ΔH=−49.4 kJ…

A: Given , Reaction : 2OF2(g) →O2(g) +2F2(g) ∆H=-49.4 kJ

Q: C 다 12/pd-C DỊCH, L 2) H3O+ ?

Q: How to run a TLC of phytochemicals extracted by hexane and acetyl acetate

A: In order to understand the TLC of phytochemicals, we first need to get the clear understanding of…

Q: Do polymerization reactions tend to have △Sorxn values that are greater than zero or less than zero?…

A: •Here ∆S° is entropy change for reaction. •ENTROPY:-Entropy defines the randomness of system , means…

Q: 1. i) Fill in the boxes with the missing reagent(s). ii) Label each reaction as an "oxidation" or…

Q: Consider the following reaction at equili- №₂ (g) + 3H₂(g) AH = + 92.4K5 2NH3 (8) Ce chatelier's…

A: Le Chatelier's principle: This principle is used to predict the effect of a change in conditions on…

Q: Which of the following contains a set of incorrectly paired words? * Chelatometry - Complexation /…

A: Here we have to choose the incorrectly paired words and Lewis base in a complexation reaction-

Q: ОН Сон o Н 0 OH здо : NH3 NH₂ 1 0 O OH NH2 H 1 Фо. Н Н -NH2 НО Н.

A: Please find the attachment.

Q: но Н…... ОН H Но Hun ОН

A: The protons present in different environment are said to be non equivalent and give different…

Q: 1 Predict the major product from the reaction shown below? C1₂ a) 1,3-dichloro-1-methylcyclohexane…

Q: I mix 100 mL of 0.100 M HCl in 250 mL of 0.150 M NH3. I add 50.0 mL of 0.0500 M NaOH. What is the…

Q: polymerization reactions tend to have △Sorxn values that are greater than zero or less than zero?…

A: Entropy is degree of randomness or disorderness in system. In polymerization □Srxn is less than…

Q: Calculate equivalent weight of unknown acid using the following information: Mass of unknown acid=…

A: Given,Mass of an unknown acid = 0.1351 gVolume of NaOH used to titrate the acid = 11.5…

Q: An aqueous solution is prepared by dissolving 1.50 g of hemocyanin, a protein obtained from crabs,…

Q: 3) A student places 120.0 mL of liquid water at 23.4 °C into a calorimeter and then dissolves 12.5 g…

A: It is an endothermic reaction. Detail solution is given in step 2.

Q: Which of the following statements about precipitation requirements is incorrect? O The precipitant…

A: In precipitation titration, the titrant reacts with analyte and forms an insoluble compound which is…

Q: Calculate the off of each of the following solutions. 2.1 X 10-4 M Ba(OH)₂, pH = 2 (13.1 X10-4 M…

Q: 2. (a). Compound B is an effective medication used to treat major depression by inhibiting the…

Q: At 25 °C, the vapor pressures of pure benzene (C6H6) and pure toluene (C7H8) are 95.1 and 28.4 mmHg,…

Q: sond 14 13 O Doublet (d) O Singlet (s) Given the molecule above, what would be the observed…

A: Signal in a 1H NMR spectrum may or may not be split into one or more peaks. This is known as signal…

Q: 6. How many electrons, protons and neutrons, respectively, are in 60 Ni 2+2 a. 26, 28, 32 b. 28, 28,…

Q: Describe the main differences between ionic, covalent, and metallic State two important…

A: Solution : Here are the main differences between ionic, covalent and metallic :

Q: Balance the following reaction (remember to show '1' when necessary) Li₂O + Al(OH)3 →→ •LIOH+A1203…

Q: Consider these reactions: Reaction 1: H₂(g) + Cl₂(g) → 2HCl(g) Reaction 2: 20F2 (g) → O₂(g) + 2 F₂…

Q: Calculate grams of sucrose that must be added to 432.3 grams of water to prepare a 8.48 % by mass…

Q: . Aluminum metal is produced by passing an electric current through a solution of aluminum oxide…

Q: Can you explain how to find the structure? And how to fill the NMR problem set

Q: The rate constant of a certain reaction is known to obey the Arrhenius equation, and to have an…

Q: A chemist dissolves 213. mg of pure barium hydroxide in enough water to make up 130. mL of solution.…

A: pH of a solution is defined as the negative log of the hydrogen ion concentration. pOH of a solution…

Q: 3. Two particles with spin states |2 - 2) and 1 1), are placed in a box. Identify the possible…

Q: Question 11 For the following sequence, fill in any missing reagents/products. تين الي PhyP KOIBu HO…

Q: A solution which contains 49.6 g of an unknown molecular compound in 395 g of water freezes at…

Q: A factory uses electrolysis to generate calcium from molten calcium chloride. Their goal for a…

A: Mass of Ca = 5.0 kg = 5000 g

Q: Please give the best resonance and second best resonance for SO2. Please explain why the best…

A: The stability of resinance structure is directly related with formal charges , octet completion and…

Q: Identify the appropriate atoms by selecting each atom and assigning it a map number of 1 until all…

A: A carbon molecule is chiral when it is attached to 4 different atoms or groups.

Q: 2. Starting from 1-propyne as your sole carbon source for the product, provide the steps required…

A: prop-1-yne undergo reduction with No/Lig NEB to give propens which undergo addition reaction to…

Q: 14. Determine if the following statements for SN2 reactions are True (T) or False (F) by circling…

Q: Consider the reaction: kJ 2SO₂(g) + O₂(g)2SO3(g) AH=-198.2 mol How would the concentrations of SO₂,…

A: According to Le chatelier's principle" if an equilibrium is subjected to a change, equilibrium will…

Q: Consider these reactions: Reaction 1: H2(g)+Cl2(g)⟶2HCl(g)ΔH=−184.6 kJ Reaction 2:…

Q: m Br way Br TI cl

Q: 2Na (s) + H₂SO (aq) - Na 4 What volume (in L) of hydrogen gas is produced at STP when 11.5 g of…

Q: 27 AM Mon Jul 25 U Take Quiz How many chiral centers are there in the following structures? . CHOH…

A: To answer the following questions.

Question

Show a reasonable mechanism for the following reaction (Hint: Michael addition followed by
intramolecular aldol condensation)
☆
NaOEt,
EtOH
A

Expert Solution

This question has been solved!

Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.

SEE SOLUTION Check out a sample Q&A here

Step 1

VIEW

Step 2

VIEW

Step 3

VIEW

Step by step

Solved in 3 steps with 3 images

SEE SOLUTION Check out a sample Q&A here

Knowledge Booster

Protection of Groups in Organic Synthesis

Learn more about

Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, chemistry and related others by exploring similar questions and additional content below.

Similar questions

Draw the structures A, B and C for the reaction sequence below. Dehydration via an E1cb mechanism Michael Reaction Intramolecular Aldol Reaction A В КОН /ETOH / heat C КОН /ETOH КОН /ETOH
Which of the following most readily forms a cyclic hemiacetal with acid catalysis? You are wreen dharing Stop Share A' но но CH3 CH3 но но
The following is a key step in the synthesis of morphine involving the conversion of A to B. Draw a stepwise mechanism for this process, including an intramolecular alkylation and intramolecular aldol.A B A CHO SO2 Br N K2CO3 B N S02
• Using aldol or crossed aldol condensation, suggest a synthesis of the following compounds: a b مليمت H3C H3C CH3 H3C ge H Saved
The Stork reaction is a condensation reaction between an enamine donor and an α,β-unsaturated carbonyl acceptor. The overall reaction consists of a three-step sequence of formation of an enamine from a ketone, Michael addition to an α,β-unsaturated carbonyl compound, and hydrolysis of the enamine in dilute acid to regenerate the ketone. Consider the Stork reaction between cyclohexanone and propenal Draw the structure of the product of the enamine formed between cyclohexanone and dimethylamine. - Michael addition to an α,β-unsaturated carbonyl compound, and - hydrolysis of the enamine in dilute acid to regenerate the ketone.
Which reagent(s) would accomplish the synthesis showWn below? NH2 NH2 но. H3CO. A) NaBH4 В) РСС C) LAH D) Na2Cr207 / H2SO4 E) NAOH www w
Propse a mechanism for the following reaction:
Reaction benzaldehyde with (CH3CN) in presence of base called ? (a) Dopner reaction (b)Crossed Claisen condensation (C) Cope reaction (d) Aldol condensation 10:00 PM
) Cinnamaldehyde is used in artificial cinnamon flavoring. Show how cinnamaldehydeis synthesized by a crossed aldol condensation followed by dehydration.H CHcinnamaldehyde C COH(b) Adding acetophenone slowly to a cold solution of LDA produces the enolate of acetophenone; but adding LDA slowly to a cold solution of acetophenone produces acondensation product. Show the reactions happening in each case, and explain why weobserve such different results
Give the IUPAC name of the two carbonyl compounds reacted together to synthesize compound A, given below, by a crossed aldol condensation followed by dehydration. || CH3CCH=CH₂2 A
What carbonyl compound and what phosphonium ylide are needed to synthesize the following compounds?
The first steps in the synthesis of azelnidipine, a calcium channel blocker, involves the reaction of β-keto ester A with aldehyde B in the presence of base. What crossed aldol product is formed in this reaction?