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- Assign the absolute configuration of the chirality center as R or S. CH2 HC "CH,Br C(CH3)3 F3C° R OsIdentify each molecule as Chiral or Achiral and write the number of Asymmetric carbons present in each chiral molecules. T) 3 - Chloro- 2- butanol H- -HO- H- -HO- H- -HO- H- -OH ČH2OH U) V)There are eight chirality centers in the following molecule. Identify each asymmetric carbon atom by clicking on the circled carbons that are chiral. HO
- 5. Consider the following pairs of structures. Identify the relationship between them (enantiomers, diastereomers, or identical compounds. HOH2C H OH H OH HO H Br H3C Н H H₂CH₂C CI Br H CHO CH3 I CH3 OH OHC Н H OH H OH Bell!! H3C, HO H Н.С H CH₂CH3 CH3 CI HỌ,H CH₂OH BrDetermine and label the configuration of each chiral carbon in the molecule shown below. HN B O FI OH The molecule shown below is the synthetic drug Latuda (Lurasidone) that is prescribed for antipsychotic for the treatment of schizophrenia in adults and adolescents (13-17 years). Examine the molecule carefully and answer the following questions. H 'N (S) H INH (R) (S) (R) IH H (S) O (S) a) Identify and label the functional groups in the molecule. b) Confirm the configuration of each stereogenic (R/S) center the molecule. c) Label the hybridization of all the nitrogen atoms in the molecule d) Circle of the most basic atom in the molecule and estimate the pKa of the conjugate acid of the base.Determine if the following compounds are chiral or achiral. Put an "X" in the box for chiral and a "0" for achiral. H3C H H3C Br -Br H H₂C- H- H -Br -Br CH3 *** Br H- Br- HO COOH -H -OH -H COOH OH
- 1. Identify the configuration of each chiral center in the following compounds. Draw the enantiomer for each of the following compounds. a) b) c) ОН ΘΗ OH H CH₂CH₂OH 1Classify the following compounds as chiral, achiral (but not meso), or meso. 1st structure: 2nd structure: 3rd structure: H HO ÇO₂HIdentify the absolute configuration of the chirality centers in each of the following compounds as R or S. Note: if multiple chirality centers are present, indicate the stereochemical designations as: RR, SS, RS, or SR. (Other terms used for chirality center include chiral center, stereocenter, and stereogenic center.) Co,H OH CO2H D. H H2N H HO2C OH CO,H HO CO2H b.) a.) d.) CO,H H H2N CO2H f) HO g.) h.)
- Identify if the following compound has R or S chirality. H3C OH HO. 0-P-O OH None R(a) assign R or S configuration to each chiral center, (b) Which compound are enantiomers? (c) Which compounds are diastereomers?Coibacin B is a natural product that exhibits potent anti-inflammatory activity and potential activity in the treatment of leishmaniasis, a disease caused by certain parasites. Assign the configuration of each chiral center in coibacin B H.
