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- Rank thr stability of the following sets of reaction intermediates.Here is the same figure as in the previous two questions, but omitting the red circles. Cys157 Cys157 Cys157 His296 His296 His296 LOH HN HN HN N? -CO2 CH2 Asn329 Asn329 Asn329- Cys157 His296 LOH HN H HyC. Asn329 Which of the following roles is played by the imidazole side chain of His296? Pick the one best [ Select ] answer.Draw the mechanism of the following alkylation reaction that occurs via an enolate intermediate. о сн, о сн, (1) LDA Ph-C-CH-CH, Ph-C-C-CH, (2) Ph — CH, — Вr ČH,-Ph
- Expain the mechanism of given reactionConsider the taollowing transtormation to answer the 3-part question. "Br OH CI 2 i) Can substrate 1 undergo intramolecular SN2 reaction? | Select] ii) Can substrate 2 undergo intramolecular SN2 reaction? [ Select ] iii) Can substrate 3 undergo intramolecular SN2 reaction? ( Select )In the following reaction, iodine monochloride (ICI) effectively serves as a source of an electrophilic lodonium species, l'U. Org. Chem 2005, 70, 3511-3517). Propose a mechanism for the formation of each of the two products, A and B. OMe Fr A MeO ICI OMe B
- A) Describe substrate structure and condition that favor SN1 reactions taking place over SN2. B) What conditions promote E2 reactions.Identify A and B in the following reaction sequence. Label each process asconrotatory or disrotatory.Please draw PLP-dependent mechanisms for this reaction. General acids/bases may be involved as needed