QUESTION 1A macromolecule binding to its ligand at 1x 10Mis considered weak binding.TrueO FalseQUESTION 2For protein structure determined using X-ray difraction with the 1.1-Angatrom resolution, the electron density of the hydrogeon atoms becomesclearly visibleTrueFalseQUESTION 3In Creutzfeldt-Jakob disease, the native prion proteins that are alpha rich in the structure are mistolded to beta rich structures that nucleate to forman amyloid iber. These prion proteins are extremely stable at physiological temperaturesTrueFalseQUESTION 4is a high-pressure cell homogenizer used for generating cell lysate.

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Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Question 1 Amyloid Precursor Protein (APP) is actually thought to be a natural neuroprotective agent induced by neuronal stress or injury. O True O False Question 2 Which of the following is not a property of serine protease? A globular protein with high molecular weight ● It is initially synthesized as a zymogen It has uniquely activated tyrosine residue at the active site Cleaves polypeptide at a specific amino acid residue Question 3 RTK is activated by cyclic AMP. O True False
Question 19 Based on the hydropathic index plot below, where in the 3D structure of the protein would you expect to find amino acid number 185? 40 Hydrophobic 20 -20 -40 Hydrophilic 40 60 80 100 120 140 160 180 200 220 240 Residue number Alpha helix Beta sheet O Double helix O Quaternary contact O Interior of the protein O Surface of the protein Hydropathic index 20
QUESTION 28 Multiple Choice: What type of interaction leads to the formation of scrapies-associated fibrils (SAFS) that are associated with prion diseases? O Intersubunit beta sheets Intrasubunit beta sheets Domain-swapped alpha helices Metal ions bound between subunits QUESTION 29 True/False: The types noncovalent interactions that give a protein its tertiary structure are the same as those that are involved in giving a protein quaternary structure O True False O O
Question 14 The folding of an unfolded protein proceeds from low entropy disordered state to a single high entropy, low energy native conformation O True O False Question 15 The GroES subunit has 14 identical 549-residue subunits arranged in two stacked rings with 7 subunits eac True False
QUESTION 23 The pl of hen lysozyme is 11.0; the pl of hen ovalbumin is 4.6. An isoelectric focussing experiment is conducted. Which of these two proteins will migrate closest to the negative pole? hen lysozyme Both proteins will remain at the origin Hen ovalbumin
QUESTION A test protein contains the following 4 ratios of its amino acid content (mg/g) vs the amino acid content in the adult reference pattern (mg/g): histidine 0.80, isoleucine 0.62, methionine + cysteine 0.50, tryptophan 0.60. What is the test protein's amino acid score (AAS)? O 0.80 O 0.62 O 0.60 O 0.50 O Cannot calculate given this information QUESTION Based on question 25, what is/are the limiting amino acid(s) in this test protein? O Histidine O Isoleucine O Methionine + cysteine O Tryptophan O Cannot calculate given this information QUESTION The test protein referred to in question 25 and 26 has a digestibility of 90%. What is the protein digestibility-corrected amino acid score (PDCAAS)? O 0.80 O 0.56 O 0.50 O 0.45 O Cannot calculate given this information
QUESTION 10 In the deoxy state of HB, which of the following does not occur? O An intra-chain salt bridge between Val 98 and Tyr 145. O An intra-chain salt bridge between Histidine 146 and Aspartate 94 side chains O A peptide bond between Tyr 145 and His 146. O An inter-chain salt bridge between Histidine 146 and Lys 40
Question 5 The core protein of a proteoglycan is noncovalently attached to: O oligosaccharides. glycosaminoglycans O keratin sulfate. O hyaluronic acid backbone
Question 13 The binding of seven molecules of ATP at the apical domain of the GroES causes the conversion of the complex from the taut to relaxed state allowing folding of the protein O True O False Question 14 The folding of an unfolded protein proceeds from low entropy disordered state to a single high entropy, low energy native conformation O True O False Question 15 1 The GroES subunit has 14 identical 549-residue subunits arranged in two stacked rings with 7 subunits eac True False
Question 39 What technique below is often used to identify transmembrane segments of integral proteins? O hydrophilicity plot hydropathy plot O Lineweaver-Burk plot titration plot
Question 12 In the tertiary structure of a protein, the R-group of valine can interact with the R-group of via a _ O leucine; hydrophobic interaction O lysine, electrostatic interaction O threonine, hydrogen bond alanine; hydrogen bond
QUESTION 7 Plotted in this graph are data from two Fluorescence Recovery After Photobleaching (FRAP) experiments. Which of the following explains the difference between the two sets of data? fluorescence O time The cell indicated by the solid line was assayed at a lower temperature than the cell indicated by the dashed line. The cell indicated by the solid line has more saturated fatty acids in its phospholipids. The cell indicated by the solid line has longer fatty acids chains in its phospholipids than the cell indicated by the dashed line. The membrane of the cell indicated by the solid line is comprised of fatty acids rather than Ophospholipids.

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