Propranolol binds to beta-adrenergic receptors with a Kj of 8.9 x 10-9M. What concentration of propranolol would be required to achieve a 50% reduction in the binding of the receptor agonist isoproterenol if the agonist concentration is 10nM and its dissociation constant for the receptor is 4.8 x 10-8 M?
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- A 35 year old male was taken to the hospital with excruciating pain in the lower abdominal area. It was discovered that this patient drank no more than half a glass of water each day over the past week, while drinking at least three cups of black tea on the same days. Additionally, the patient regularly eats very large quantities of spinach. Upon further analysis, it was determined that the presence of Calcium Iodideand Sodium Oxalate may have led to the pain that the patient was experiencing. Determine whether or not kidney stones could be the probable cause of the lower abdominal pain for this patient by answering the following questions (Be sure to show your work for all parts): Assume that Calcium Iodideand Sodium Oxalate are the starting substances (reactants) in the reaction: a. Write a balanced chemical equation describing the formation of kidney stones, using the information in the case study. b. State the names of the products that are produced from this reaction. c.…A 35 year old male was taken to the hospital with excruciating pain in the lower abdominal area. It was discovered that this patient drank no more than half a glass of water each day over the past week, while drinking at least three cups of black tea on the same days. Additionally, the patient regularly eats very large quantities of spinach. Upon further analysis, it was determined that the presence of Calcium Iodideand Sodium Oxalate may have led to the pain that the patient was experiencing. Determine whether or not kidney stones could be the probable cause of the lower abdominal pain for this patient by answering the following questions (Be sure to show your work for all parts): Assume that Calcium Iodideand Sodium Oxalate are the starting substances (reactants) in the reaction: a. Write a balanced chemical equation describing the formation of kidney stones, using the information in the case study. b. State the names of the products that are produced from this reaction. c.…A 35 year old male was taken to the hospital with excruciating pain in the lower abdominal area. It was discovered that this patient drank no more than half a glass of water each day over the past week, while drinking at least three cups of black tea on the same days. Additionally, the patient regularly eats very large quantities of spinach. Upon further analysis, it was determined that the presence of Calcium Iodideand Sodium Oxalate may have led to the pain that the patient was experiencing. Determine whether or not kidney stones could be the probable cause of the lower abdominal pain for this patient by answering the following questions (Be sure to show your work for all parts): Assume that Calcium Iodideand Sodium Oxalate are the starting substances (reactants) in the reaction: a. Write a balanced chemical equation describing the formation of kidney stones, using the information in the case study. b. State the names of the products that are produced from this reaction. c.…
- A 35 year old male was taken to the hospital with excruciating pain in the lower abdominal area. It was discovered that this patient drank no more than half a glass of water each day over the past week, while drinking at least three cups of black tea on the same days. Additionally, the patient regularly eats very large quantities of spinach. Upon further analysis, it was determined that the presence of Calcium Iodideand Sodium Oxalate may have led to the pain that the patient was experiencing. Determine whether or not kidney stones could be the probable cause of the lower abdominal pain for this patient by answering the following questions (Be sure to show your work for all parts): Assume that Calcium Iodideand Sodium Oxalate are the starting substances (reactants) in the reaction: a. Write a balanced chemical equation describing the formation of kidney stones, using the information in the case study. b. State the names of the products that are produced from this reaction. c.…A 35 year old male was taken to the hospital with excruciating pain in the lower abdominal area. It was discovered that this patient drank no more than half a glass of water each day over the past week, while drinking at least three cups of black tea on the same days. Additionally, the patient regularly eats very large quantities of spinach. Upon further analysis, it was determined that the presence of Calcium Iodideand Sodium Oxalate may have led to the pain that the patient was experiencing. Determine whether or not kidney stones could be the probable cause of the lower abdominal pain for this patient by answering the following questions (Be sure to show your work for all parts):On the following page are three compounds, 1, 2, and 3, that have been investigated as anti-malarial candidates. Compound 1 is the "parent" molecule, and 2 and 3 are derivatives. Shown next to each molecule is (i) the enthalpy change when it binds to its target, and (ii) the dissociation constant for the molecule/target complex. Consider the structures and answer the following: AH = - 1.2 kcal/mol; Kp = 16 nM OH 1 HO AH = - 6.0 kcal/mol; Kp = 76 nM OH AH = - 5.5 kcal/mol; Kp = 0.5 nM OH 3 (i) What is the difference among 1, 2, and 3?
- If the G for a reaction is 4.5 kcal/mol at 298 K, what is the Keq for this reaction? What is the change in entropy of this reaction if H = 3.2 kcal/mol?The standard free energy of hydrolysis, DG of some compounds are given below: Compound DG (kcal/mole) Compound A-P (APA + P₁) -5.7 Compound B-P (BPB+ P₁) -10.3 Compound C-P (CPC + P₁) -7.5 Compound D-P (DPD + P₁) -4.6 Compound E-P (EP-E + P₁) -6.1 Which of the following reactions will occur spontaneously? B+ CP C+ BP CP+E EP + C O AP+C CP+ A EP+BE+ BP OAnswer ALL parts of this question. An aspirin tablet dissolved in sodium hydroxide solution gave sodium salicylate. The sodium salicylate gives a yellow colour and absorbs at 295 nm, which gave an estimated concentration of sodium salicylate of 0.00015 mol dm-³. CO₂H NaOH (aq) CO₂Na OH sodium salicylate Aspirin (a) Explain the formation of sodium salicylate using a curly arrow mechanism. (b) The solution of sodium salicylate was diluted to 50 cm³. How many moles are in the 50 cm³? (c) There were initially 250 cm³ of the original aspirin solution, so the total number of moles of sodium salicylate in the original solution is 250 times that calculated in part (b). Calculate the mass of aspirin in the tablet. (MW of aspirin = 180 gmol-¹).
- Tom, an analytical chemist, bought a bag of decaffeinated coffee from a grocery store. However,Tom suspected that he might have received regular coffee and therefore decided to analyze hiscoffee for caffeine. In the lab, he took 0.5 mL of the brewed coffee and diluted it in water tomake a 100.0 mL solution. He performed four analyses and found the concentrations to be 4.69,3.99, 4.12, and 4.50 mg/L, respectively. (Assume the density of all solutions is 1.000 g/mL,1oz= 28.35 mL).(a) Report the concentration (in mg/L) of caffeine in the brewed coffee using the format asaverage ± standard deviation. (Note this is not the concentration in the diluted solution.)(b) Look up the caffeine content of regular vs. decaffeinated coffee. Do you think that Tom wasgiven the wrong type of coffee?(c) Caffeine intake of 300 mg per day reportedly has no adverse effects in the vast majority ofthe adult population. If Tom drinks 3 cups (8 oz/cup) of this coffee daily, is his intake withinthis known safe…Given the following data: 2C6H6 (l) + 15O2 (g) → 12CO2 (g) + 6 H2O (l) ΔG° = –6399 kJ C (s) + O2 (g) → CO2 (g) ΔG° = –394 kJ H2 (g) + ½ O2 (g) → H2O(l) ΔG° = –273 kJ Calculate ΔG° for the reaction 6 C(s) + 3 H2(g) ----> C6H6(l) ΔG° = ???Bromoscresol green, Ka = 2.0 x 10-5 is yellow in its protonated form (HX) and blue in its ionized form (X-). At what pH will bromoscresol green be a perfect green colour? Express your answer to one decimal place.