Propose a metabolic I pathway for methotrexate
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- Describe the mechanism of a-chymotrypsin. Explain the roles of constituents of the catalytic triad, their modes of catalysis, and the significance of the oxyanion hole in the catalysis.Diazepam is converted in vivo to an active metabolite Oxazepam. Explain metabolic transfomation of diazepam to oxazepam. (Provide names of enzymes involved in this transformation. Drawings of structures ofintemediate metabolites is NOT required)Sterol Biosynthesis A) Identify and draw the mechanism of the steps of the prenyltransferase reaction. B) Define statin and identify which enzyme is inhibited by statins.
- Briefly describe the role of nucleophilic catalysis in the mechanism of the chymotrypsin reaction.Describe the application of transamination in the biosynthesis of shikimate derivatives. Show how the isoflavone is obtained from flavanones. What is the primary reaction involved?Explain biochemical pathways mechanistically. Describe the β-oxidation pathway. Describe the conversion of propionyl CoA to succinyl CoA. Describe the substrate activation processes in the urea cycle (CPS 1 and arginosuccinate synthetase).
- Provide a reasonable step-wise mechanism for the reaction below, involving TPP as acoenzyme (can abbreviate the pyrophosphate as R), and invoking any general acids or base fromacetolactate synthase that you might need .Provide an example of covalent catalysis in the mechanism of chymotrypsin. What is the nucleophile involved in the formation of this covalent bond? What enabled this group to become a good nucleophile?Using the principles described in the text regarding pyridoxal phosphate mechanisms, propose a mechanism for the reaction catalyzed by serine hydroxymethyltransferase.