Procaine (its hydrochloride is marketed as Novocain) was one of the first local anesthet- ics for infiltration and regional anesthesia. See "Chemical Connections: From Cocaine to Procaine and Beyond."According to the following retrosynthetic scheme, procaine can be synthesized from 4-aminobenzoic acid, ethylene oxide, and diethylamine as sources of carbon atoms. HO. + HO NEt, H,N H,N' Procaine 4-Aminobenzoic acid Et,NH Ethylene oxide Diethylamine Provide reagents and experimental conditions to carry out the synthesis of procaine from these three compounds.
Procaine (its hydrochloride is marketed as Novocain) was one of the first local anesthet- ics for infiltration and regional anesthesia. See "Chemical Connections: From Cocaine to Procaine and Beyond."According to the following retrosynthetic scheme, procaine can be synthesized from 4-aminobenzoic acid, ethylene oxide, and diethylamine as sources of carbon atoms. HO. + HO NEt, H,N H,N' Procaine 4-Aminobenzoic acid Et,NH Ethylene oxide Diethylamine Provide reagents and experimental conditions to carry out the synthesis of procaine from these three compounds.
Organic Chemistry
8th Edition
ISBN:9781305580350
Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Chapter18: Functional Derivatives Of Carboxylic Acids
Section: Chapter Questions
Problem 18.42P
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