PEDIGREES: Problem 7 (continued) This pedigree shows the inheritance of a type of X-linked color blindness. It is a recessive trait. Carriers have NOT been half-shaded in this pedigree. 2 3 I 어디어ㅁ II 2 3 QUESTIONS 3. Use the letter "b" to represent the color blindness allele. What is the genotype of individual IV-? bb 4. What evidence is there that this type of color blindness is recessive? III IV 2 3 1

PEDIGREES: Problem 7 (continued) This pedigree shows the inheritance of a type of X-linked color blindness. It is a recessive trait. Carriers have NOT been half-shaded in this pedigree. 2 3 I 어디어ㅁ II 2 3 QUESTIONS 3. Use the letter "b" to represent the color blindness allele. What is the genotype of individual IV-? bb 4. What evidence is there that this type of color blindness is recessive? III IV 2 3 1

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Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter16: Reproductive Technology, Genetic Testing, And Gene Therapy

Section: Chapter Questions

Problem 18QP

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Need help, please. What are the ratios for the progeny phenotype(s)?
A. Look at the pedigree, and DISREGARD individual II-8 for the moment. Is the pattern of inheritance of Unetan syndrome dominant or recessive? You may assume that the gene is FULLY-PENETRANT in this family. Please give two specific reasons that support your conclusion. B. Now, looking at BOTH the pedigree AND at the Southern blot, is this trait autosomal, X-linked, or Y-linked? Please give two specific reasons that support your conclusion. Once again, disregard II-8 for the moment. One of your two reasons must refer specifically to evidence present in the Southern blot. C. Define the gene alleles associated with Unetan syndrome. Your alleles MUST be consistent with the pattern of inheritance, AND your genetic notation must be consistent with that used throughout the course. Unetan syndrome allele: ________ Normal allele: ________
Below are 9 possible primer pairs.● Determine which primer pair is the best choice.● Explain why the other primers are not good choices.● Calculate the Tm for each primer. Underline or highlight the region of DNA for the primer pair you chose as the best.Forward 1: 5’ gaaataattttgtttaactttaag 3’ Tm =Reverse 1: 5’ gtttaagacaaaatagtctgg 3’ Tm =Forward 2: 5’ gtaactcagctttcaggtcg 3’ Tm =Reverse 2: 5’ tctcggaatgttgcaacagc 3’ Tm =Forward 3: 5’ agattagcggatcctacctg 3’ Tm =Reverse 3: 5’ atgtgtaatcccagcagcag 3’ Tm =Forward 4: 5’ cattgattatttgcacggcg 3’ Tm =Reverse 4: 5’ aaaatcttctctcatccgcc 3’ Tm =Forward 5: 5’ tccataagattagcggatcc 3’ Tm =Reverse 5: 5’ tgcaagcttggctgttttgg 3’ Tm =Forward 6: 5’ gatcctacctgacgcttttta 3’ Tm=Reverse 6: 5’ aaataatgaattcgagctcggt 3’ Tm =Forward 7: 5’ataaaaaaatcgagataaccgtt 3’ Tm =Reverse 7: 5’aggtcgactctagaggatc 3’ Tm =Forward 8: 5’ctacctgttccatggccaac 3’ Tm=Reverse 8: 5’ ttcgggcatggcactcttg 3’ Tm=Forward 9: 5’ tccataagattagcggatcc 3’ Tm =Reverse 9: 5’…
Both karyotyping and G_banding techniques show normal chromosomal pattern, however pedigree analysis revealed abnormality of genetic origin, what are the reasons of this?
Susan’s grandfather was deaf, and passed down a hereditary form of deafness within Susan’s family as shown in Figure Q19–12.A. Is this mutation most likely to be dominant or recessive?B. Is it carried on an autosome or a sex chromosome? Why?C. A complete SNP analysis has been done for all of the 11 grandchildren (4 affected, and 7 unaffected). In comparing these 11 SNP results, how long a haplotype block would you expect to find around the critical gene? How might you detect it?
Both karyotyping and G_banding techniques show normal chromosomal pattern, however pedigree analysis revealed abnormality of genetic origin, can you think of a reason that would explain the findings?
Pedigree Analysis Is a Basic Method in Human Genetic: What does OMIM stand for? What kinds of information are in this database?
Familial retinoblastoma, a rare autosomal dominant defect, arose in a large family that had no prior history of the disease. Consider the following pedigree (the darkly colored symbols represent affected individuals): a. Circle the individual(s) in which the mutation most likely occurred. b. Is the person who is the source of the mutation affected by retinoblastoma? Justify your answer. c. Assuming that the mutant allele is fully penetrant, what is the chance that an affected individual will have an affected child?
1. Duchenne’s muscular dystrophy (DMD) is a devastating X-linked recessive disease that causes muscle wasting and is eventually fatal. Meredith’s brother Craig has DMD but Meredith is healthy. You may find it beneficial to draw the family pedigree. a) What is the simple probability (as a percentage) that Meredith is a carrier of a mutation causing DMD? b) Meredith herself has two healthy children, a boy and a girl. Is this anterior (ancestral) or posterior (modifying) information? c) If Meredith IS a carrier for DMD (i.e. scenario A is correct), what is the probability (as a percentage) of her having these two healthy children?
Prader-Willi syndrome is caused by a mutation in anautosomal maternally imprinted gene. Label the following statements as true or false, assuming that thetrait is 100% penetrant.a. Sons of affected males have a 50% chance of showing the syndrome.b. Daughters of affected males have a 50% chance ofshowing the syndrome.c. Sons of affected females have a 50% chance ofshowing the syndrome.d. Daughters of affected females have a 50% chanceof showing the syndrome.
Please answer all parts along with the reason. I'll definitely give a like. Thank you in advance! 1A) From the cross Ab/aB x ab/ab, what is the recombination frequency if the progeny numbers are 17 AB/ab, 72 Ab/ab, 68 aB/ab, and 21 ab/ab? 1B)In human gene mapping, a LOD score is calculated to see if a gene causing a rare disease is linked to a known SNP. The LOD score is -4. This means that 1C) A three-point testcross is used to determine the order of three linked genes. The following crossover progeny result: single crossovers, double crossovers, and no crossovers. To determine the order, the no-crossover progeny must be compared to what other class of progeny?
You have identified a SNP marker that in one largefamily shows no recombination with the locus causinga rare hereditary autosomal dominant disease.Furthermore, you discover that all afflicted individuals in the family have a G base at this SNP on theirmutant chromosomes, while all wild-type chromosomes have a T base at this SNP. You would like tothink that you have discovered the disease locus andthe causative mutation but realize you need to consider other possibilities.a. What is another possible interpretation of the results?b. How would you go about obtaining additional genetic information that could support or eliminateyour hypothesis that the base-pair difference is responsible for the disease?