Paul is a 23-year-old. He was the victim of a hit-and-run auto-pedestrian accident and suffered multiple abrasions, a concussion, and a deep laceration of his left thigh. He was discovered approximately 2 hours after the incident and is now in the emergency department. Paul’s vital signs and hematocrit suggest that he has had a blood loss of about 2,500 ml. A urinary catheter is inserted to monitor urine output, and fluid resuscitation is initiated while his wounds are cleaned and sutured. The urine output is averaging 15 ml/hr, with a high urine osmolality and low urine sodium. Without adequate therapy, what may develop? Why? What is the best therapy for preventing this from occurring?

Principles Of Pharmacology Med Assist
6th Edition
ISBN:9781337512442
Author:RICE
Publisher:RICE
Chapter25: Diuretics And Medications Used For Urinary System Disorders
Section: Chapter Questions
Problem 7RQ
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Paul is a 23-year-old. He was the victim of a hit-and-run auto-pedestrian accident 
and suffered multiple abrasions, a concussion, and a deep laceration of his left 
thigh. He was discovered approximately 2 hours after the incident and is now in 
the emergency department. Paul’s vital signs and hematocrit suggest that he has 
had a blood loss of about 2,500 ml. A urinary catheter is inserted to monitor urine 
output, and fluid resuscitation is initiated while his wounds are cleaned and 
sutured. The urine output is averaging 15 ml/hr, with a high urine osmolality and 
low urine sodium. 

Without adequate therapy, what may develop? Why? What is the best 
therapy for preventing this from occurring?

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