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Pathway analysis: Link the protein names to the correct statements by interrogating the depicted pathway. Options: A. RTK Receptor Threonine Kinase B. GEF Guanidine Exchange Factor C. PLC Phospholipase C D. GAP GTPase Activating Protein E. Gαi F. Raf Rapidly Accelerated Fibrosarcoma G. PAK1 p21 Activated Kinase H. WASP Wiscott Aldrich syndrome protein I. RTK Receptor Tyrosine Kinase J. GPCR G-protein Coupled Receptor K. Steroid Receptor L. Phosphatase M. MEK1 (Mitogen-Activated Protein) Kinase/ERK (Extracellular Signal-Regulated Kinase) Kinase 1 N. AC Adenylyl cyclase O. IP3R IP3 Receptor P. ERK1/2 Extracellular Signal-Regulated Kinase

Pathway analysis: Link the protein names to the correct statements by interrogating the depicted pathway. Options: A. RTK Receptor Threonine Kinase B. GEF Guanidine Exchange Factor C. PLC Phospholipase C D. GAP GTPase Activating Protein E. Gαi F. Raf Rapidly Accelerated Fibrosarcoma G. PAK1 p21 Activated Kinase H. WASP Wiscott Aldrich syndrome protein I. RTK Receptor Tyrosine Kinase J. GPCR G-protein Coupled Receptor K. Steroid Receptor L. Phosphatase M. MEK1 (Mitogen-Activated Protein) Kinase/ERK (Extracellular Signal-Regulated Kinase) Kinase 1 N. AC Adenylyl cyclase O. IP3R IP3 Receptor P. ERK1/2 Extracellular Signal-Regulated Kinase

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Question

Pathway analysis: Link the protein names to the correct statements by interrogating the depicted pathway.

Options:

A.

RTK Receptor Threonine Kinase
B.

GEF Guanidine Exchange Factor
C.

PLC Phospholipase C
D.

GAP GTPase Activating Protein
E.

Gαi
F.

Raf Rapidly Accelerated Fibrosarcoma
G.

PAK1 p21 Activated Kinase
H.

WASP Wiscott Aldrich syndrome protein
I.

RTK Receptor Tyrosine Kinase
J.

GPCR G-protein Coupled Receptor
K.

Steroid Receptor
L.

Phosphatase
M.

MEK1 (Mitogen-Activated Protein) Kinase/ERK (Extracellular Signal-Regulated Kinase) Kinase 1
N.

AC Adenylyl cyclase
O.

IP3R IP3 Receptor
P.

ERK1/2 Extracellular Signal-Regulated Kinase
CHEMOKINE SIGNALING PATHWAY Eosinophil Neutrophil Macrophage T lymphocyte Cytokine-cytokine receptor interaction chemokinechemkireR 04062 8/24/20 (c) Kanehisa Laboratories +p AC Gai GBy JAK2/3 Gag PKA CAMP GRK B-arrestin 1 Receptor internalization * Src PLC +p Jak-STAT signaling pathway +p Shc Class IA PI3K PI3K Class IB +p +p +p * FAK IP3 DAG GRB2 +p PIP3 Itk Pyk2 Ca STAT +p +p SOS P-Rex1 DOCK2 ELMO1 Vav MAPK signaling pathway Raf Ras PKC Akt Paxillin p130Cas Crk CalDAG-GEF1 RasGRP2 Rapl PKC IKK +p BAD +P GSK3 Rac Tiaml Par3 PKCC ✔ Cdc42 Pyk2 p47phox NADPH oxidase MEK1 ERK1/2 FOXO NFkB + +p IKB | ↓ Ubiquitin mediated proteolysis PAK1 +p WASP RhoA FAK p130Cas Crk Paxillin ROCK Cytokine production Cellular growth and differentiation. Cell survival DNA Migration Apoptosis Leukocyte transendotherial migration Migration Chemotaxis Cellular shape changes Mete stasis Degranulation ROS production Regulation of ac tin cytoskeleton Degranulation NO induction Migration ROS production
Transcribed Image Text:CHEMOKINE SIGNALING PATHWAY Eosinophil Neutrophil Macrophage T lymphocyte Cytokine-cytokine receptor interaction chemokinechemkireR 04062 8/24/20 (c) Kanehisa Laboratories +p AC Gai GBy JAK2/3 Gag PKA CAMP GRK B-arrestin 1 Receptor internalization * Src PLC +p Jak-STAT signaling pathway +p Shc Class IA PI3K PI3K Class IB +p +p +p * FAK IP3 DAG GRB2 +p PIP3 Itk Pyk2 Ca STAT +p +p SOS P-Rex1 DOCK2 ELMO1 Vav MAPK signaling pathway Raf Ras PKC Akt Paxillin p130Cas Crk CalDAG-GEF1 RasGRP2 Rapl PKC IKK +p BAD +P GSK3 Rac Tiaml Par3 PKCC ✔ Cdc42 Pyk2 p47phox NADPH oxidase MEK1 ERK1/2 FOXO NFkB + +p IKB | ↓ Ubiquitin mediated proteolysis PAK1 +p WASP RhoA FAK p130Cas Crk Paxillin ROCK Cytokine production Cellular growth and differentiation. Cell survival DNA Migration Apoptosis Leukocyte transendotherial migration Migration Chemotaxis Cellular shape changes Mete stasis Degranulation ROS production Regulation of ac tin cytoskeleton Degranulation NO induction Migration ROS production
✓ What type of protein is the chemokine receptor? ✓ TIAM acts as what type of regulator on Rac? ✓ Loss or inactivation of which protein will lead to increased cAMP (cyclic AMP)? ✓ Which protein in this diagram is responsible for actin nucleation? ✓ Which protein not shown in this diagram is directly responsible for the Calcium release in the cell? Which protein is designated as a MAPKK in this diagram?
Transcribed Image Text:✓ What type of protein is the chemokine receptor? ✓ TIAM acts as what type of regulator on Rac? ✓ Loss or inactivation of which protein will lead to increased cAMP (cyclic AMP)? ✓ Which protein in this diagram is responsible for actin nucleation? ✓ Which protein not shown in this diagram is directly responsible for the Calcium release in the cell? Which protein is designated as a MAPKK in this diagram?
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