Part Where does the mutation that causes this disorder occur? O. The mutation occurs on the DNA The mutation occurs on the RNA O. The mutation occurs on the ribosomes The mutation occurs on the amino acid Part B: Which BEST describes the result of this mutation? O The entire sequence of amino acids is changed O. The RNA strand does not code for the correct amino acids The change in amino acids shortens the polypeptide sequence

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Chapter6: Dna Structure And Function
Section: Chapter Questions
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Question 20
XXIXX!
Proteins
Proteins are determined by the structure of DNA and RNA. DNA consists of two chains of nucleotides held together by chemical bonds. Base pairing rules determine how the bases of each chain will bond to one another. RNA also has
repeating nucleotides, bases that are held together by chemical bonds, and specific base pairing rules, but it is a single strand and has different bases than DNA. The sequence of DNA is rewritten into an RNA copy which then determines
the sequence of amino acids of a polypeptide chain, the primary structure of a protein. A single amino acid is added to the protein strand for every 3 bases, or codons, in the RNA. The sequence of amino acids determines the way the
protein will fold. The folding of the protein determines its function. The structure of DNA, RNA, and a protein are shown.
DNA
First nucleotide
U
с
A
G
The triplet codon used to decipher the amino acids is mostly universal. Each amino acid has more than one codon. Methionine (AUG) is the initiation codon that starts the translation process. There are 3 codons that stop the translation
process.
UUU
UUC
UUA
UUG
CUU
CUC
CUA
CUG
RNA
GUU
GUC
GUA
GUG
U
(Phe
Leu
(Leu
AUU
AUC
AUA
AUG (Met)
lle
Protein
Val
UCU
UCC
UCA
UCG
CCU
CCC
CCA
CCG
ACU
ACC
ACA
ACG
GCU
GCC
GCA
GCG
Ser
Pause
Pro
Thr
Q
Second nucleotide
с
Ala
Folded
protein
Q Zoom
CAU
CAC
CAA
CAG
UAU
Tyr
UAC
UAA STOP
UAG STOP
AAU
AAC
AAA
AAG
A
GAU
GAC
GAA
GAG
His
Gln
(Asn
Lys
Asp
Glu
UGU
Cys
UGC
STOP
UGA
UGG Trp
CGU
CGC
CGA
CGG
AGU
AGC
AGA
AGG
G
GGU
GGC
GGA
GGG
(Arg)
Ser
Arg
Gly
U
с
A
U
G
A
G
Third nucleotide
The following question has two parts. First, answer Part A. Then, answer Part B.
Caused by a mutation, sickle cell anemia is a disorder that affects hemoglobin, the red blood cell molecule that carries oxygen to cells throughout the body. The ß chain of the hemoglobin protein is a
single chain of amino acids and is 147 amino acids long. In humans, the gene that encodes for the ß chain is located on chromosome 11. The diagrams show the DNA, RNA, and amino acid sequence of
an unaffected person and a person with sickle cell anemia.
Unaffected person
GAC TGA GGA CTC CTC
Amino Acids -Leu-Thr - Pro-
O
O
O
Amino Acids
A.
O
DNA
B.
RNA
C.
D.
DNA
Part A:
Where does the mutation that causes this disorder occur?
CUG ACU CCU GAG GAG
Person with sickle cell anemia
RNA
Glu - Glu
GAC TGA GGA CAC CTC
CUG ACU CCU GUG GAG
-Leu-Thr -Pro-Val-Glu
The mutation occurs on the DNA.
The mutation occurs on the RNA.
The mutation occurs on the ribosomes.
The mutation occurs on the amino acid.
Part B:
Which BEST describes the result of this mutation?
A. The entire sequence of amino acids is changed.
O
B. The RNA strand does not code for the correct amino acids.
Q Review / ✓ Finish Test
O
C. The change in amino acids shortens the polypeptide sequence.
ABC
Transcribed Image Text:Question 20 XXIXX! Proteins Proteins are determined by the structure of DNA and RNA. DNA consists of two chains of nucleotides held together by chemical bonds. Base pairing rules determine how the bases of each chain will bond to one another. RNA also has repeating nucleotides, bases that are held together by chemical bonds, and specific base pairing rules, but it is a single strand and has different bases than DNA. The sequence of DNA is rewritten into an RNA copy which then determines the sequence of amino acids of a polypeptide chain, the primary structure of a protein. A single amino acid is added to the protein strand for every 3 bases, or codons, in the RNA. The sequence of amino acids determines the way the protein will fold. The folding of the protein determines its function. The structure of DNA, RNA, and a protein are shown. DNA First nucleotide U с A G The triplet codon used to decipher the amino acids is mostly universal. Each amino acid has more than one codon. Methionine (AUG) is the initiation codon that starts the translation process. There are 3 codons that stop the translation process. UUU UUC UUA UUG CUU CUC CUA CUG RNA GUU GUC GUA GUG U (Phe Leu (Leu AUU AUC AUA AUG (Met) lle Protein Val UCU UCC UCA UCG CCU CCC CCA CCG ACU ACC ACA ACG GCU GCC GCA GCG Ser Pause Pro Thr Q Second nucleotide с Ala Folded protein Q Zoom CAU CAC CAA CAG UAU Tyr UAC UAA STOP UAG STOP AAU AAC AAA AAG A GAU GAC GAA GAG His Gln (Asn Lys Asp Glu UGU Cys UGC STOP UGA UGG Trp CGU CGC CGA CGG AGU AGC AGA AGG G GGU GGC GGA GGG (Arg) Ser Arg Gly U с A U G A G Third nucleotide The following question has two parts. First, answer Part A. Then, answer Part B. Caused by a mutation, sickle cell anemia is a disorder that affects hemoglobin, the red blood cell molecule that carries oxygen to cells throughout the body. The ß chain of the hemoglobin protein is a single chain of amino acids and is 147 amino acids long. In humans, the gene that encodes for the ß chain is located on chromosome 11. The diagrams show the DNA, RNA, and amino acid sequence of an unaffected person and a person with sickle cell anemia. Unaffected person GAC TGA GGA CTC CTC Amino Acids -Leu-Thr - Pro- O O O Amino Acids A. O DNA B. RNA C. D. DNA Part A: Where does the mutation that causes this disorder occur? CUG ACU CCU GAG GAG Person with sickle cell anemia RNA Glu - Glu GAC TGA GGA CAC CTC CUG ACU CCU GUG GAG -Leu-Thr -Pro-Val-Glu The mutation occurs on the DNA. The mutation occurs on the RNA. The mutation occurs on the ribosomes. The mutation occurs on the amino acid. Part B: Which BEST describes the result of this mutation? A. The entire sequence of amino acids is changed. O B. The RNA strand does not code for the correct amino acids. Q Review / ✓ Finish Test O C. The change in amino acids shortens the polypeptide sequence. ABC
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