NHCH3cat. H*.CH3CH3CH2CHONH2CH3The Mannich reaction is one of the few three-component reactions in organic chemistry. In this reaction, a ketone, an aldehyde and an amine react together under acid catalyzedform the final product. The mechanism involves the following steps:1. Following initial protonation of the carbonyl oxygen, nucleophilic attack by the amine forms a protonated carbinolamine 1;2. Proton transfer and elimination of water forms iminium ion 2;3. The enol form of the ketone attacks the iminium ion to form adduct 3;4. Deprotonation of adduct 3 leads to the final product.Write out the mechanism on a separate sheet of paper and then draw the structure of adduct 3.• You do not have to consider stereochemistry.• You do not have to explicitly draw H atoms.• Do not include lone pairs in your answer. They will not be considered in the grading.opy asteO= Draw the structure(s) of the organic product(s) of the Claisen condensation reaction between ethyl acetate and ethyl benzoate.• You do not have to consider stereochemistry.• Draw only the condensation product, including the self-condensation product if applicable. Do not draw the structure of the leaving group.Draw one structure per sketcher. Add additional sketchers using the drop-down menu in the bottom right corner.• Separate multiple products using the + sign from the drop-down menu.оруasteChemDoodle®||

The step by step mechanism is shown below:-

NHCH3 cat. H* .CH3 CH3CH2CHO + NH2CH3 The Mannich reaction is one of the few three-component reactions in organic chemistry. In this reaction, a ketone, an aldehyde and an amine react together under acid catalyzed form the final product. The mechanism involves the following steps: 1. Following initial protonation of the carbonyl oxygen, nucleophilic attack by the amine forms a protonated carbinolamine 1; 2. Proton transfer and elimination of water forms iminium ion 2; 3. The enol form of the ketone attacks the iminium ion to form adduct 3; 4. Deprotonation of adduct 3 leads to the final product. Write out the mechanism on a separate sheet of paper and then draw the structure of adduct 3.

NHCH3 cat. H* .CH3 CH3CH2CHO + NH2CH3 The Mannich reaction is one of the few three-component reactions in organic chemistry. In this reaction, a ketone, an aldehyde and an amine react together under acid catalyzed form the final product. The mechanism involves the following steps: 1. Following initial protonation of the carbonyl oxygen, nucleophilic attack by the amine forms a protonated carbinolamine 1; 2. Proton transfer and elimination of water forms iminium ion 2; 3. The enol form of the ketone attacks the iminium ion to form adduct 3; 4. Deprotonation of adduct 3 leads to the final product. Write out the mechanism on a separate sheet of paper and then draw the structure of adduct 3.

Organic Chemistry: A Guided Inquiry

2nd Edition

ISBN:9780618974122

Author:Andrei Straumanis

Publisher:Andrei Straumanis

Chapter13: Substitution

Section: Chapter Questions

Problem 2E

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