Mutations in DNA may or may not result in a change in the phenotype of an organism. In which of the following situations will a mutation appear in the phenotype of an individual? O The mutation occurs in an organism which is past reproductive age O The genetic code for protein synthesis has not been altered in a gamete producing cell O The mutation occurs in a body cell of the organism, resulting in cancer O The mutation results in a change in the amino acid sequence of the protein in a gamete producing cell
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- Genetic mutations can provide insights into the mechanisms of complex cellular or developmental processes. How might your analysis of a genetic mutation be different depending on whether a particular mutation is recessive or dominant?One unexpected result of the sequencing of the human genome was the finding that mutations in a single gene can be responsible for multiple distinct disorders. For example, mutations in the RET gene can cause two different types of multiple endocrine neoplasias, familial medullary thyroid carcinoma, and Hirschsprung disease. How do you think mutations in a single gene can have such diverse effects?Duchenne Muscular Dystrophy (DMD) is a disease that manifests in muscle weakness. It exhibits X-linked recessive inheritance pattern. The dystrophin gene is large and can have many different mutations along the DNA. From the following mutations between the gene sequence (DNA template strand) of a healthy male and an affected brother determine if they would affect the production of mRNA or the sequence of the protein. Base your analysis on the position of the mutation in the transcription unit, and the impact of the change on the codons. Mutation 1: Position -6 Healthy individual A Affected brother C Group of answer choices A. Normal mRNA, normal protein B. No mRNA produced (promoter affected) C. Abnormal mRNA, affected protein D. Normal mRNA, affected protein Base your analysis on the position of the mutation in the transcription unit, and the impact of the change on the codons.
- How do germ-line mutations differ from somatic mutations? Germ-line mutations are reversible, while somatic mutations are not. Germ-line mutations result in mutant gametes, while somatic mutations do not. Germ-line mutations occur during DNA replication, while somatic mutations do not. Germ-line mutations result in cancers, while somatic mutations do not. Germ-line mutations involve small changes to DNA such as base-pair substitutions, while somatic mutations involve large deletions.Is it acceptable or not to edit the genome of human embryos to treat genetic diseases? There is a group of genetic disorders that cause fatal childhood diseases. To avoid having children with these genetic disorders, some parents choose to use a procedure called in vitro fertilization (IVF) followed by genetic testing. Typically, in the first step of IVF, women receive hormone injections to produce multiple eggs, after which the eggs are harvested. The eggs are then fertilized by sperm in a petri dish to make embryos, which are then transferred to a woman's uterus. If the goal is to identify embryos that do not have specific genetic conditions, doctors would screen the embryos before they are implanted into the woman - in other words, they would analyze the embryos' DNA to look for variants of the gene(s) that cause the genetic disorder. While the genetic testing of IVF-produced embryos has been done for decades, the procedure is controversial. The controversies include worries that…Gene mutations can be classified in two major ways:(1) hereditary or germline mutations that are inherited from a parent and are present throughout a person’s life in virtually every cell in the body.(2) acquired or somatic mutations that occur at some time during a person’s life and are present only in certain cells, not in every cell in the body.If there is no family history of a particular disease but a child has the disease then it may have arisen due to a(n) ________ mutation early during development. A) acquired B) inherited C) silent D) transition
- Which of the following can occur when genes are not expressed properly? it can result in uncontrolled cell growth, forming tumors the DNA of the cell will be destroyed by RNA only the proteins needed by the specific cell are created genes will create carbohydrates instead of proteinsWhich of the following genetic changes would be passed from parent to child? A duplication of chromosome 21 during mitosis in a pancreas cell The addition of a chromosome in an egg cell A mutation in a skin cell caused by UV light A translocation in a nonhomologous pair of chromosomes in a liver cellMutagens, when introduced to the body can always cause cancer. Is this statement true? Select the correct response: No. Mutagens do not necessarily, directly equate to the cause of cancer. A cancer is usually caused by a substance called carcinogen that increases the probability of inducing a tumor. Mutagens can be limited to the result of spontaneous or induced mutations that causes changes and/or errors in the coding and reading of the DNA strand and in the genetic make- up of the organism involved. Though some mutagens are considered as carcinogens, not all mutagens can lead to cancer. Yes. The terms can be used interchangeably even in the medical field. Yes. Mutagens does equate to the cause of cancer. A cancer is usually caused by a substance called carcinogen that increases the probability of inducing a tumor. However, mutagens is not only limited to the result of spontaneous or induced mutations that causes changes and/or errors in the coding and reading of the DNA strand and in…
- In many organisms, the sex of the organism is determined by its genețic code. In most mammals, including humans, the sex of the organism is determined by genes that fall on specific chromosomes called the X and Y chromosomes. Most mammals have two sex chromosomes. A mammal cell with two X chromosomes is from a organism and a mammal cell with one X and one Y chromosome is from a organism. In humans, the SRY gene is responsible for in cells. This gene occurs onResearchers have identified a gene in humans that (when mutant)causes severe dwarfism and mental impairment. This disorder isinherited in an autosomal recessive manner, and the mutant alleleis known to be a loss-of-function mutation. The same gene hasbeen found in mice, although a mutant version of the gene has notbeen discovered in mice. To develop drugs and an effective therapyto treat this disorder in humans, it would be experimentallyuseful to have a mouse model. In other words, it would be desirableto develop a strain of mice that carry the mutant allele in thehomozygous condition. Experimentally, how would you developsuch a strain?Any permanent change to the structure of DNA is considered a mutation. A somatic cell mutation affects only the individual organism, while a germline mutation is passed onto the next generation. For example, excessive amount of exposure to UV rays can lead to skin cancer. Although this type of mutation occurs in the somatic cells, every individual has different susceptibility to skin cell mutations upon exposure to UV rays. The susceptibility is located in the germ cell and is heritable. The individuals who choose to overexpose themselves to UV rays increase their likelihood of obtaining undesirable mutations in their somatic cells. Unlike suntanning, there are other activities we engage in that can lead to germline mutations. These activities should be avoided if possible as they lead to heritable mutations and cancer. Using 200 words or less, identify one human activity that can lead to a heritable mutation. Explain how it affects the individual and how it can be passed onto the…