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- Genetic disorders Complete the following statements to describe several genetic disorders and their symptoms. Choices can be used more than once. The disorder called causes blue-colored skin, sickle-cell disease osteogenesis imperfecta The disorder called that leads to weakened, brittle bones. causes defective collagen methemoglobinemia autosomal dominant The disorder called causes abnormally thick mucus in the bronchial tubes and pancreatic ducts. autosomal recessive The disorder called leads to progressive cystic fibrosis degeneration of neurons in the brain. alkaptonuria The disorder called causes urine to be black. Huntington disease acer %23 24 & 4 8. 9. e y u < 6Describe in words the likely transmission of an autosomal dominant disorder. Include details of the parent’s genotype and subsequent pattern and probability of inheritance of the single gene disorder for the offspring produced and provide an example of an autosomal dominant disorderIn autosomal dominant disorders, the recurrence risk is ¾(75%) when one affected parent and one carrier parent produce an offspring . True or false
- A patient has two parents with Huntington's disease. They may not have inherited this autosomal dominant disorder due to: 1) increased DNA repeats (CAG) during spermatogenesis 2) incomplete penetrance 3) inheriting one recessive alleleReview the process of autosomal dominant inheritance by coloring the following figures. In this instance the father is affected in the mother is unaffected to illustrate the transmission of the disorder from the father to the children color the figures as described.Achondroplasia is an autosomal dominant disorder characterized by disproportionate short stature: the legs and arms of people with achondroplasia are short compared with the head and trunk. The disorder is due to a base substitution in the gene, located on the short arm of chromosome 4, that encodes fibroblast growth factor receptor 3 (FGFR3). Although achondroplasia is clearly inherited as an autosomal dominant trait, more than 80% of the people who have achondroplasia are born to parents with normal stature. This high percentage indicates that most cases are caused by newly arising mutations; these cases (not inherited from an affected parent) are referred to as sporadic. Studies have demonstrated that sporadic cases of achondroplasia are almost always caused by mutations inherited from the father (paternal mutations). In addition, the occurrence of achondroplasia is higher among the children of older fathers; approximately 50% of children with achondroplasia are born to fathers…