Make an electron-flow-mechanism for this synthetic scheme. This involves predicting major and by. products using electronic and structural effects. The arrow push mechanism must be shown. (4-bromo-3- nitroacetophenone to flurbiprofen) with label

Physical Chemistry
2nd Edition
ISBN:9781133958437
Author:Ball, David W. (david Warren), BAER, Tomas
Publisher:Ball, David W. (david Warren), BAER, Tomas
Chapter2: The First Law Of Thermodynamics
Section: Chapter Questions
Problem 2.51E: With regard to exercise 2.50, how accurate do you think your answer is, and why?
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Make an electron-flow-mechanism for this synthetic scheme. This involves predicting major and by. products using electronic and structural effects. The arrow push mechanism must be shown. (4-bromo-3- nitroacetophenone to flurbiprofen) with label

O,N
CH3
reduction
Br
Cu
2
3
Schieman reaction
cooc,Hs
COOH
HN.
ELOH
H2SO4
S. heat
(1) CH,0 oC,Hs, NaOC,Hs
(2) Me,sO,
CH3
CH
cOOH
(1) NaOH
(2) 180-200 °Č
7
O
Transcribed Image Text:O,N CH3 reduction Br Cu 2 3 Schieman reaction cooc,Hs COOH HN. ELOH H2SO4 S. heat (1) CH,0 oC,Hs, NaOC,Hs (2) Me,sO, CH3 CH cOOH (1) NaOH (2) 180-200 °Č 7 O
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