Looking at Fig. 3a and 3b, how do you know that 3a has a significant difference and that Fig. 3b does not? In the euthyroid HT induces ultrastructure changes in frontal synapses section of the results section the authors wrote “Quantitatively, the ultrastructure of the frontal lobe neurons revealed lower synaptic density (Fig. 5c), fewer presynaptic vesicles (Fig. 5d), shorter active zone length (Fig. 5e), thinner postsynaptic densities (Fig. 5g), and decreased synaptic curvature (Fig. 5h) in the HT mice compared with those in the Con mice.” Based on this quote would you expect nerve transmission to be faster or slower in HT mice?
Looking at Fig. 3a and 3b, how do you know that 3a has a significant difference and that Fig. 3b does not? In the euthyroid HT induces ultrastructure changes in frontal synapses section of the results section the authors wrote “Quantitatively, the ultrastructure of the frontal lobe neurons revealed lower synaptic density (Fig. 5c), fewer presynaptic vesicles (Fig. 5d), shorter active zone length (Fig. 5e), thinner postsynaptic densities (Fig. 5g), and decreased synaptic curvature (Fig. 5h) in the HT mice compared with those in the Con mice.” Based on this quote would you expect nerve transmission to be faster or slower in HT mice?
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Looking at Fig. 3a and 3b, how do you know that 3a has a significant difference and that Fig. 3b does not?
In the euthyroid HT induces ultrastructure changes in frontal synapses section of the results section the authors wrote “Quantitatively, the ultrastructure of the frontal lobe neurons revealed lower synaptic density (Fig. 5c), fewer presynaptic vesicles (Fig. 5d), shorter active zone length (Fig. 5e), thinner postsynaptic densities (Fig. 5g), and decreased synaptic curvature (Fig. 5h) in the HT mice compared with those in the Con mice.” Based on this quote would you expect nerve transmission to be faster or slower in HT mice?
Transcribed Image Text:Fig. 3
From: Synaptic loss in a mouse model of euthyroid Hashimoto's thyroiditis: possible involvement of the n
Orientation navigation test
b
a
Escape latency (s)
50
40
30
10
*HHH
*1
HH
Con
HT
Day1 Day2 Day3 Day4 Day5
Trainning days
Swimming speed(cm/sec)
0.25-
0.20-
0.15-
0. 10-
0.05-
0.00-
T
Con
HT
Spatial probe test
Transcribed Image Text:Fig. 5
From: Synaptic loss in a mouse model of euthyroid Hashimoto's thyroiditis: possible involvement of the microglia
a
b
C
d
Synapse density (/μm³) Number of vesicles
2.0-
1.5-
1.0
0.5-
0.0-
Con
*
T
120.0₁
90.0-
60.0-
30.0-
0.0
HT
e
Active zone length (µm)
0.8₁
0.6-
0.4-
0.2-
*
f
HT
0.04₁
0.03-
0.02-
0.01-
0.00-
AZ
Con
Synaptic cleft (µm)
ns
g
PSD thickness (µm)
0.12-
0.09-
0.06-
0.03-
0.00-
*
SC
h
HT
Synaptic curvature
2.0₁
1.5-
1.0
0.5-
0.0
Con HT
Con
Con HT
Con HT
Con HT
Con HT
Euthyroid HT induces ultrastructure changes in frontal synapses. a Representative EM images of synapses (arrowheads). b Representative EM images of
synaptic interface; V represents synaptic vesicles; the synaptic active zone is indicated by white arrows; SC represents the synaptic cleft; PSD is indicated by
black arrowheads. c-h Quantitation of the synaptic interface, including synapse density (c), number of vesicles (d), active zone length (e), synaptic cleft (f),
PSD thickness (g), and synaptic curvature (h). Data are the mean ± SEM (n = 4 mice/group); Scale bars: a = 500 nm; b = 200 nm
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