Let's imagine that in a drug design project a problem is encountered with the low water solubility of a lead compound. The compound has the low melting point of 41-43°C, and a log P value of 4.95. The compound does not possess any ionizable basic or acidic functional groups. Suggest two kinds of modification that the design team could introduce to increase the water solubility of the lead compound. Modification 1: Modification 2:

Let's imagine that in a drug design project a problem is encountered with the low water solubility of a lead compound. The compound has the low melting point of 41-43°C, and a log P value of 4.95. The compound does not possess any ionizable basic or acidic functional groups. Suggest two kinds of modification that the design team could introduce to increase the water solubility of the lead compound. Modification 1: Modification 2:

Fundamentals Of Analytical Chemistry

9th Edition

ISBN:9781285640686

Author:Skoog

Publisher:Skoog

Chapter21: Potentiometry

Section: Chapter Questions

Problem 21.22QAP

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